4-(2-{4-[2-(4-phenyloxycarbonylphenyl)ethynyl]phenyl}ethynyl)benzoic acid

Base Information

Chemical Name:4-(2-{4-[2-(4-phenyloxycarbonylphenyl)ethynyl]phenyl}ethynyl)benzoic acid
CAS No.:866825-57-2
Molecular Formula:C₃₀H₁₈O₄
Molecular Weight:442.471
Hs Code.:

Synonyms:4-(2-{4-[2-(4-phenyloxycarbonylphenyl)ethynyl]phenyl}ethynyl)benzoic acid

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Chemical Property of 4-(2-{4-[2-(4-phenyloxycarbonylphenyl)ethynyl]phenyl}ethynyl)benzoic acid

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Technology Process of 4-(2-{4-[2-(4-phenyloxycarbonylphenyl)ethynyl]phenyl}ethynyl)benzoic acid

There total 3 articles about 4-(2-{4-[2-(4-phenyloxycarbonylphenyl)ethynyl]phenyl}ethynyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 866825-56-1
phenyl 4-[2-(4-ethynylphenyl)ethynyl]benzoate

: 619-58-9
4-iodobenzoic acid

: 866825-57-2
4-(2-{4-[2-(4-phenyloxycarbonylphenyl)ethynyl]phenyl}ethynyl)benzoic acid

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; triethylamine; triphenylphosphine; copper(l) iodide; In tetrahydrofuran; at 50 ℃;
DOI:10.1021/ja053120l

Reference yield:

: 4-(4-ethynyl-phenylethynyl)-benzoyl chloride

: 866825-57-2
4-(2-{4-[2-(4-phenyloxycarbonylphenyl)ethynyl]phenyl}ethynyl)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 2.7 g / pyridine / CH₂Cl₂ / 5 - 20 °C

2: 77 percent / PPh₃; PdCl₂(PPh₃)2; Et₃N / CuI / tetrahydrofuran / 50 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; triethylamine; triphenylphosphine; copper(l) iodide; In tetrahydrofuran; dichloromethane; 2: Sonogashira coupling;
DOI:10.1021/ja053120l

Reference yield:

: potassium 4-[2-(4-ethynylphenyl)ethynyl]benzoate

: 866825-57-2
4-(2-{4-[2-(4-phenyloxycarbonylphenyl)ethynyl]phenyl}ethynyl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 5 - 20 °C

2: 2.7 g / pyridine / CH₂Cl₂ / 5 - 20 °C

3: 77 percent / PPh₃; PdCl₂(PPh₃)2; Et₃N / CuI / tetrahydrofuran / 50 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; triphenylphosphine; copper(l) iodide; In tetrahydrofuran; dichloromethane; 3: Sonogashira coupling;
DOI:10.1021/ja053120l