2-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-3,5-dicyanopyridin-4-yl]phenoxy}ethyl L-glutaminate hydrochloride

Base Information

Chemical Name:2-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-3,5-dicyanopyridin-4-yl]phenoxy}ethyl L-glutaminate hydrochloride
CAS No.:1112459-18-3
Molecular Formula:C₃₀H₂₅ClN₆O₅S₂*ClH
Molecular Weight:685.612
Hs Code.:

Synonyms:2-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-3,5-dicyanopyridin-4-yl]phenoxy}ethyl L-glutaminate hydrochloride

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Chemical Property of 2-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-3,5-dicyanopyridin-4-yl]phenoxy}ethyl L-glutaminate hydrochloride

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Technology Process of 2-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-3,5-dicyanopyridin-4-yl]phenoxy}ethyl L-glutaminate hydrochloride

There total 2 articles about 2-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-3,5-dicyanopyridin-4-yl]phenoxy}ethyl L-glutaminate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₅H₃₃ClN₆O₇S₂

: 1112459-18-3
2-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-3,5-dicyanopyridin-4-yl]phenoxy}ethyl L-glutaminate hydrochloride

Guidance literature:: C₃₅H₃₃ClN₆O₇S₂; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 544417-40-5
Capadenoson

: 2419-94-5
Boc-Glu

: 1112459-18-3
2-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-3,5-dicyanopyridin-4-yl]phenoxy}ethyl L-glutaminate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; dmap; In dichloromethane; N,N-dimethyl-formamide;