(S)-4-methyl-3-phenylpentanoic acid isopropyl ester

Base Information

• Chemical Name: (S)-4-methyl-3-phenylpentanoic acid isopropyl ester
• CAS No.: 256220-88-9
• Molecular Formula: C₁₅H₂₂O₂
• Molecular Weight: 234.338
• Mol file: 256220-88-9.mol

Synonyms:(S)-4-methyl-3-phenylpentanoic acid isopropyl ester

Chemical Property of (S)-4-methyl-3-phenylpentanoic acid isopropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (S)-4-methyl-3-phenylpentanoic acid isopropyl ester

There total 4 articles about (S)-4-methyl-3-phenylpentanoic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

phenyllithium (591-51-5) + 2-propyl 4-methyl-trans-2-pentenoate (80229-29-4) → (S)-4-methyl-3-phenylpentanoic acid isopropyl ester (256220-88-9)

Guidance literature:

phenyllithium; With Trimethyl borate; In diethyl ether; hexane; at -78 - -20 ℃; for 1.5h;

2-propyl 4-methyl-trans-2-pentenoate; With bis(ethylene)rhodium acetylacetonate; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); In 1,4-dioxane; diethyl ether; water; at 100 ℃; for 3h;

DOI:10.1016/S0957-4166(99)00417-6

Reference yield: 28.0%

phenyl trimethylsiloxane (2996-92-1,46143-12-8) + 2-propyl 4-methyl-trans-2-pentenoate (80229-29-4) → (S)-4-methyl-3-phenylpentanoic acid isopropyl ester (256220-88-9)

Guidance literature:

With (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine); bis(acetonitrile)(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; In 1,4-dioxane; water; at 90 ℃; for 20h;

DOI:10.1016/j.tetasy.2005.12.032

Reference yield:

triphenylboroxine (3262-89-3) + 2-propyl 4-methyl-trans-2-pentenoate (80229-29-4) → (S)-4-methyl-3-phenylpentanoic acid isopropyl ester (256220-88-9) + (R)-4-Methyl-3-phenyl-pentanoic acid isopropyl ester

Guidance literature:

With potassium hydroxide; bis(ethylene)rhodium(I) chloride dimer; (1R,4R)-2,5-dibenzylbicyclo[2.2.1]hepta-2,5-diene; In 1,4-dioxane; at 50 ℃; for 1h; Title compound not separated from byproducts;

DOI:10.1021/ja037367z

upstream raw materials:

phenyllithium

2-propyl 4-methyl-trans-2-pentenoate

triphenylboroxine

phenyl trimethylsiloxane

Downstream raw materials:

(S)-(-)-3-phenyl-4-methylpentanoic acid