(1R,2R,3R,5S,6S,7S,7aR)-1,2-dibenzyloxy-3-tert-butyldiphenylsilyloxymethyl-6,7-dihydroxy-5-methylpyrrolizidine

Base Information

Chemical Name:(1R,2R,3R,5S,6S,7S,7aR)-1,2-dibenzyloxy-3-tert-butyldiphenylsilyloxymethyl-6,7-dihydroxy-5-methylpyrrolizidine
CAS No.:1361194-06-0
Molecular Formula:C₃₉H₄₇NO₅Si
Molecular Weight:637.891
Hs Code.:

Synonyms:(1R,2R,3R,5S,6S,7S,7aR)-1,2-dibenzyloxy-3-tert-butyldiphenylsilyloxymethyl-6,7-dihydroxy-5-methylpyrrolizidine

Suppliers and Price of (1R,2R,3R,5S,6S,7S,7aR)-1,2-dibenzyloxy-3-tert-butyldiphenylsilyloxymethyl-6,7-dihydroxy-5-methylpyrrolizidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,2R,3R,5S,6S,7S,7aR)-1,2-dibenzyloxy-3-tert-butyldiphenylsilyloxymethyl-6,7-dihydroxy-5-methylpyrrolizidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,2R,3R,5S,6S,7S,7aR)-1,2-dibenzyloxy-3-tert-butyldiphenylsilyloxymethyl-6,7-dihydroxy-5-methylpyrrolizidine

There total 4 articles about (1R,2R,3R,5S,6S,7S,7aR)-1,2-dibenzyloxy-3-tert-butyldiphenylsilyloxymethyl-6,7-dihydroxy-5-methylpyrrolizidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1361194-02-6
(2R,3R,4R,5R)-3,4-dibenzyloxy-N-benzyloxycarbonyl-2-tert-butyldiphenylsilyloxymethyl-5-[(1'S,2'R)-1'-2'-dihydroxy-3'-oxobutyl]pyrrolidine

: 1361194-06-0
(1R,2R,3R,5S,6S,7S,7aR)-1,2-dibenzyloxy-3-tert-butyldiphenylsilyloxymethyl-6,7-dihydroxy-5-methylpyrrolizidine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; under 3102.97 Torr; stereoselective reaction;
DOI:10.1002/ejoc.201101126

Reference yield:

: 861872-76-6
(2R,3R,4R,5R)-3,4-dibenzyloxy-N-benzyloxycarbonyl-2'-O-tert-butyldiphenylsilyl-2,5-bis(hydroxymethyl)pyrrolidine

: 1361194-06-0
(1R,2R,3R,5S,6S,7S,7aR)-1,2-dibenzyloxy-3-tert-butyldiphenylsilyloxymethyl-6,7-dihydroxy-5-methylpyrrolizidine

Guidance literature:: Multi-step reaction with 4 steps

1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 1 h / 20 °C / Molecular sieve

2: toluene / 24 h / Reflux

3: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / acetone / 20 h / 20 °C

4: palladium 10% on activated carbon; hydrogen / methanol / 3102.97 Torr

With osmium(VIII) oxide; tetrapropylammonium perruthennate; palladium 10% on activated carbon; water; hydrogen; 4-methylmorpholine N-oxide; In methanol; dichloromethane; acetone; toluene;
DOI:10.1002/ejoc.201101126

Reference yield:

: (2R,3R,4R,5S)-3,4-Bis-benzyloxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-formyl-pyrrolidine-1-carboxylic acid benzyl ester

: 1361194-06-0
(1R,2R,3R,5S,6S,7S,7aR)-1,2-dibenzyloxy-3-tert-butyldiphenylsilyloxymethyl-6,7-dihydroxy-5-methylpyrrolizidine

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / 24 h / Reflux

2: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / acetone / 20 h / 20 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 3102.97 Torr

With osmium(VIII) oxide; palladium 10% on activated carbon; water; hydrogen; 4-methylmorpholine N-oxide; In methanol; acetone; toluene;
DOI:10.1002/ejoc.201101126