4-{3-[(ethoxy)carbonyl]-2-[2-(4-trifluoromethylphenyl)ethyl]-5-oxo-1,5,8,9-tetrahydro-4H,7H-pyrazolo[1',2':1,2]pyrazolo[3,4-b]pyridin-4-yl}benzoic acid

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Chemical Name:4-{3-[(ethoxy)carbonyl]-2-[2-(4-trifluoromethylphenyl)ethyl]-5-oxo-1,5,8,9-tetrahydro-4H,7H-pyrazolo[1',2':1,2]pyrazolo[3,4-b]pyridin-4-yl}benzoic acid
CAS No.:858671-14-4
Molecular Formula:C₂₈H₂₆F₃N₃O₅
Molecular Weight:541.527
Hs Code.:

Synonyms:4-{3-[(ethoxy)carbonyl]-2-[2-(4-trifluoromethylphenyl)ethyl]-5-oxo-1,5,8,9-tetrahydro-4H,7H-pyrazolo[1',2':1,2]pyrazolo[3,4-b]pyridin-4-yl}benzoic acid

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Chemical Property of 4-{3-[(ethoxy)carbonyl]-2-[2-(4-trifluoromethylphenyl)ethyl]-5-oxo-1,5,8,9-tetrahydro-4H,7H-pyrazolo[1',2':1,2]pyrazolo[3,4-b]pyridin-4-yl}benzoic acid

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Technology Process of 4-{3-[(ethoxy)carbonyl]-2-[2-(4-trifluoromethylphenyl)ethyl]-5-oxo-1,5,8,9-tetrahydro-4H,7H-pyrazolo[1',2':1,2]pyrazolo[3,4-b]pyridin-4-yl}benzoic acid

There total 5 articles about 4-{3-[(ethoxy)carbonyl]-2-[2-(4-trifluoromethylphenyl)ethyl]-5-oxo-1,5,8,9-tetrahydro-4H,7H-pyrazolo[1',2':1,2]pyrazolo[3,4-b]pyridin-4-yl}benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 603998-98-7
ethyl 3-oxo-5-(4-trifluoromethylphenyl)pentanoate

: 619-66-9
4-Carboxybenzaldehyde

: 358360-19-7
3-amino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one hydrochloride

: 858671-14-4
4-{3-[(ethoxy)carbonyl]-2-[2-(4-trifluoromethylphenyl)ethyl]-5-oxo-1,5,8,9-tetrahydro-4H,7H-pyrazolo[1',2':1,2]pyrazolo[3,4-b]pyridin-4-yl}benzoic acid

Guidance literature:: With sodium ethanolate; In ethanol; for 8h; Heating;
DOI:10.1021/jo050370b

Reference yield:

: 1-cyanoacetylpyrazolidine hydrochloride

: 858671-14-4
4-{3-[(ethoxy)carbonyl]-2-[2-(4-trifluoromethylphenyl)ethyl]-5-oxo-1,5,8,9-tetrahydro-4H,7H-pyrazolo[1',2':1,2]pyrazolo[3,4-b]pyridin-4-yl}benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 0.5 h / Heating

2: 51 percent / NaOEt / ethanol / 8 h / Heating

With sodium ethanolate; In ethanol; 2: Hantzsch cyclization;
DOI:10.1021/jo050370b

Reference yield:

: 603998-97-6
2,2-dimethyl-5-{3-[4-(trifluoromethyl)phenyl]propanoyl}-1,3-dioxane-4,6-dione

: 858671-14-4
4-{3-[(ethoxy)carbonyl]-2-[2-(4-trifluoromethylphenyl)ethyl]-5-oxo-1,5,8,9-tetrahydro-4H,7H-pyrazolo[1',2':1,2]pyrazolo[3,4-b]pyridin-4-yl}benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / ethanol / 3 h / Heating

2: 51 percent / NaOEt / ethanol / 8 h / Heating

With ethanol; sodium ethanolate; In ethanol; 2: Hantzsch cyclization;
DOI:10.1021/jo050370b