methyl (2S,2'R,3S,3'S,3aS,4aS,5R,8S,8aR)-3-(2,5,10,10-tetramethyl-octahydro-2H-5,8-methano-isoxazolo[3,2-b]benzoxazol-3-yl)-3'-(phenylmethyloxycarbonyl)amino-2'-methylpropanoate

Base Information

Chemical Name:methyl (2S,2'R,3S,3'S,3aS,4aS,5R,8S,8aR)-3-(2,5,10,10-tetramethyl-octahydro-2H-5,8-methano-isoxazolo[3,2-b]benzoxazol-3-yl)-3'-(phenylmethyloxycarbonyl)amino-2'-methylpropanoate
CAS No.:279673-28-8
Molecular Formula:C₂₇H₃₈N₂O₆
Molecular Weight:486.609
Hs Code.:

methyl (2S,2'R,3S,3'S,3aS,4aS,5R,8S,8aR)-3-(2,5,10,10-tetramethyl-octahydro-2H-5,8-methano-isoxazolo[3,2-b]benzoxazol-3-yl)-3'-(phenylmethyloxycarbonyl)amino-2'-methylpropanoate

Synonyms:methyl (2S,2'R,3S,3'S,3aS,4aS,5R,8S,8aR)-3-(2,5,10,10-tetramethyl-octahydro-2H-5,8-methano-isoxazolo[3,2-b]benzoxazol-3-yl)-3'-(phenylmethyloxycarbonyl)amino-2'-methylpropanoate

Suppliers and Price of methyl (2S,2'R,3S,3'S,3aS,4aS,5R,8S,8aR)-3-(2,5,10,10-tetramethyl-octahydro-2H-5,8-methano-isoxazolo[3,2-b]benzoxazol-3-yl)-3'-(phenylmethyloxycarbonyl)amino-2'-methylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (2S,2'R,3S,3'S,3aS,4aS,5R,8S,8aR)-3-(2,5,10,10-tetramethyl-octahydro-2H-5,8-methano-isoxazolo[3,2-b]benzoxazol-3-yl)-3'-(phenylmethyloxycarbonyl)amino-2'-methylpropanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl (2S,2'R,3S,3'S,3aS,4aS,5R,8S,8aR)-3-(2,5,10,10-tetramethyl-octahydro-2H-5,8-methano-isoxazolo[3,2-b]benzoxazol-3-yl)-3'-(phenylmethyloxycarbonyl)amino-2'-methylpropanoate

There total 5 articles about methyl (2S,2'R,3S,3'S,3aS,4aS,5R,8S,8aR)-3-(2,5,10,10-tetramethyl-octahydro-2H-5,8-methano-isoxazolo[3,2-b]benzoxazol-3-yl)-3'-(phenylmethyloxycarbonyl)amino-2'-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 13139-17-8
N-(Benzyloxycarbonyloxy)succinimide

: 279673-27-7
methyl (2S,2'RS,3S,3'S,3aS,4aS,5R,8S,8aR)-3-(2,5,10,10-tetramethyl-ovtahydro-2H-5,8-methano-isoxazolo[3,2-b]benzoxazol-3-yl)-3'-amino-2'-methylpropanoate

: 279673-36-8
C₂₇H₃₈N₂O₆

: 279673-28-8
methyl (2S,2'R,3S,3'S,3aS,4aS,5R,8S,8aR)-3-(2,5,10,10-tetramethyl-octahydro-2H-5,8-methano-isoxazolo[3,2-b]benzoxazol-3-yl)-3'-(phenylmethyloxycarbonyl)amino-2'-methylpropanoate

Guidance literature:: With 5percent aq.NaHCO₃; In dichloromethane; for 1h;
DOI:10.1002/(sici)1099-0690(200004)2000:8<1595::aid-ejoc1595>3.3.co;2-5

Reference yield:

: 171020-83-0
(1R,2S,6R,7S)-1,10,10-Trimethyl-3-oxa-5-aza-tricyclo[5.2.1.0^2,6]dec-4-ene 5-oxide

: 279673-28-8
methyl (2S,2'R,3S,3'S,3aS,4aS,5R,8S,8aR)-3-(2,5,10,10-tetramethyl-octahydro-2H-5,8-methano-isoxazolo[3,2-b]benzoxazol-3-yl)-3'-(phenylmethyloxycarbonyl)amino-2'-methylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 10 percent / CH₂Cl₂ / reflux

2.1: Zn powder / tetrahydrofuran / 1 h / reflux

2.2: 62 percent / 50percent aq. K₂CO₃ / tetrahydrofuran / 0.5 h / 25 °C

3.1: 99 percent / NaCNBH₃; bromocresol; 2N HCl/MeOH / methanol; CH₂Cl₂ / 15 h / -90 °C

4.1: 28 percent / 5percent aq.NaHCO₃ / CH₂Cl₂ / 1 h

With hydrogenchloride; methanol; 2-bromo-6-methylphenol; sodium cyanoborohydride; zinc; In tetrahydrofuran; methanol; dichloromethane; 1.1: Cycloaddition / 2.1: Addition / 2.2: Hydrolysis / 3.1: Reduction / 4.1: Acylation;
DOI:10.1002/(sici)1099-0690(200004)2000:8<1595::aid-ejoc1595>3.3.co;2-5

Reference yield:

: 279673-26-6
methyl (2Z,4E)-3-amino-2-methyl-2,4-hexadienoate

: 279673-28-8
methyl (2S,2'R,3S,3'S,3aS,4aS,5R,8S,8aR)-3-(2,5,10,10-tetramethyl-octahydro-2H-5,8-methano-isoxazolo[3,2-b]benzoxazol-3-yl)-3'-(phenylmethyloxycarbonyl)amino-2'-methylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: MS 4 Angstroem / CH₂Cl₂ / 2 h / reflux

2: 99 percent / NaCNBH₃; bromocresol; 2N HCl/MeOH / methanol; CH₂Cl₂ / 15 h / -90 °C

3: 28 percent / 5percent aq.NaHCO₃ / CH₂Cl₂ / 1 h

With hydrogenchloride; methanol; MS 4 Angstroem; 2-bromo-6-methylphenol; sodium cyanoborohydride; In methanol; dichloromethane; 1: Cycloaddition / 2: Reduction / 3: Acylation;
DOI:10.1002/(sici)1099-0690(200004)2000:8<1595::aid-ejoc1595>3.3.co;2-5