(1R,2R)-2-(5-(4’-(2-((2S,3aS,6aS)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)octahydrocyclopenta[b]pyrrol-2-yl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid

Base Information

• Chemical Name: (1R,2R)-2-(5-(4’-(2-((2S,3aS,6aS)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)octahydrocyclopenta[b]pyrrol-2-yl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid
• CAS No.: 1445590-85-1
• Molecular Formula: C₃₈H₄₄N₆O₅
• Molecular Weight: 664.805
• Mol file: 1445590-85-1.mol

Synonyms:(1R,2R)-2-(5-(4’-(2-((2S,3aS,6aS)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)octahydrocyclopenta[b]pyrrol-2-yl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid

Chemical Property of (1R,2R)-2-(5-(4’-(2-((2S,3aS,6aS)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)octahydrocyclopenta[b]pyrrol-2-yl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R)-2-(5-(4’-(2-((2S,3aS,6aS)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)octahydrocyclopenta[b]pyrrol-2-yl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid

There total 20 articles about (1R,2R)-2-(5-(4’-(2-((2S,3aS,6aS)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)octahydrocyclopenta[b]pyrrol-2-yl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C42H52N6O5 → (1R,2R)-2-(5-(4’-(2-((2S,3aS,6aS)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)octahydrocyclopenta[b]pyrrol-2-yl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid (1445590-85-1)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 48h;

Reference yield:

L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) → (1R,2R)-2-(5-(4’-(2-((2S,3aS,6aS)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)octahydrocyclopenta[b]pyrrol-2-yl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid (1445590-85-1)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium hydroxide; sodium carbonate / 4 h / 20 °C / Cooling with ice

2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0 - 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate / 1,4-dioxane / 80 °C / Inert atmosphere

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; potassium fluoride dihydrate / water; benzene; ethanol / 1 h / Inert atmosphere; Microwave irradiation

5: hydrogenchloride / water / 48 h / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride dihydrate; potassium acetate; sodium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; benzene;

Reference yield:

N-methoxycarbonyl-L-valine (111398-44-8,74761-42-5) → (1R,2R)-2-(5-(4’-(2-((2S,3aS,6aS)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)octahydrocyclopenta[b]pyrrol-2-yl)-1H-imidazol-5-yl)-[1,1‘-biphenyl]-4-yl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid (1445590-85-1)

Guidance literature:

Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0 - 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate / 1,4-dioxane / 80 °C / Inert atmosphere

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; potassium fluoride dihydrate / water; benzene; ethanol / 1 h / Inert atmosphere; Microwave irradiation

4: hydrogenchloride / water / 48 h / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride dihydrate; potassium acetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; benzene;

upstream raw materials:

L-valine

N-methoxycarbonyl-L-valine

ethyl 2-oxocyclohexane carboxylate

cis-1,2-cyclopentanedicarboxylic acid

Refernces