Azepane-1-carboxylic acid {(S)-1-[4-(4-benzyloxy-phenylamino)-piperidine-1-carbonyl]-3-methyl-butyl}-amide

Base Information

Chemical Name:Azepane-1-carboxylic acid {(S)-1-[4-(4-benzyloxy-phenylamino)-piperidine-1-carbonyl]-3-methyl-butyl}-amide
CAS No.:220737-64-4
Molecular Formula:C₃₁H₄₄N₄O₃
Molecular Weight:520.715
Hs Code.:

Synonyms:Azepane-1-carboxylic acid {(S)-1-[4-(4-benzyloxy-phenylamino)-piperidine-1-carbonyl]-3-methyl-butyl}-amide

Suppliers and Price of Azepane-1-carboxylic acid {(S)-1-[4-(4-benzyloxy-phenylamino)-piperidine-1-carbonyl]-3-methyl-butyl}-amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Azepane-1-carboxylic acid {(S)-1-[4-(4-benzyloxy-phenylamino)-piperidine-1-carbonyl]-3-methyl-butyl}-amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Azepane-1-carboxylic acid {(S)-1-[4-(4-benzyloxy-phenylamino)-piperidine-1-carbonyl]-3-methyl-butyl}-amide

There total 4 articles about Azepane-1-carboxylic acid {(S)-1-[4-(4-benzyloxy-phenylamino)-piperidine-1-carbonyl]-3-methyl-butyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 111-49-9
hexamethylene imine

: 220737-64-4
Azepane-1-carboxylic acid {(S)-1-[4-(4-benzyloxy-phenylamino)-piperidine-1-carbonyl]-3-methyl-butyl}-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / CH₂Cl₂ / 1.5 h / -10 °C

1.2: 88 percent / CH₂Cl₂ / 48 h / 20 °C

2.1: 92 percent / H₂ / 20 percent Pd/C / tetrahydrofuran / 16 h / 2585.74 Torr

3.1: diisopropylethylamine; HBTU / dimethylformamide / 1 h

With pyridine; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1.1: chloroformylation / 1.2: Condensation / 2.1: Hydrogenolysis / 3.1: Condensation;
DOI:10.1021/jm9902739

Reference yield:

: 1738-69-8
L-Leucine benzyl ester

: 220737-64-4
Azepane-1-carboxylic acid {(S)-1-[4-(4-benzyloxy-phenylamino)-piperidine-1-carbonyl]-3-methyl-butyl}-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / CH₂Cl₂ / 1.5 h / -10 °C

1.2: 88 percent / CH₂Cl₂ / 48 h / 20 °C

2.1: 92 percent / H₂ / 20 percent Pd/C / tetrahydrofuran / 16 h / 2585.74 Torr

3.1: diisopropylethylamine; HBTU / dimethylformamide / 1 h

With pyridine; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1.1: chloroformylation / 1.2: Condensation / 2.1: Hydrogenolysis / 3.1: Condensation;
DOI:10.1021/jm9902739

Reference yield:

: 141595-75-7
(S)-2-[(azepane-1-carbonyl)-amino]-4-methyl-pentanoic acid benzyl ester

: 220737-64-4
Azepane-1-carboxylic acid {(S)-1-[4-(4-benzyloxy-phenylamino)-piperidine-1-carbonyl]-3-methyl-butyl}-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / H₂ / 20 percent Pd/C / tetrahydrofuran / 16 h / 2585.74 Torr

2: diisopropylethylamine; HBTU / dimethylformamide / 1 h

With hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Hydrogenolysis / 2: Condensation;
DOI:10.1021/jm9902739