(S)-2-(2-Methylamino-acetylamino)-3-phenyl-propionic acid methyl ester

Base Information

• Chemical Name: (S)-2-(2-Methylamino-acetylamino)-3-phenyl-propionic acid methyl ester
• CAS No.: 119767-54-3
• Molecular Formula: C₁₃H₁₈N₂O₃
• Molecular Weight: 250.298
• Mol file: 119767-54-3.mol

Synonyms:(S)-2-(2-Methylamino-acetylamino)-3-phenyl-propionic acid methyl ester

Chemical Property of (S)-2-(2-Methylamino-acetylamino)-3-phenyl-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(2-Methylamino-acetylamino)-3-phenyl-propionic acid methyl ester

There total 1 articles about (S)-2-(2-Methylamino-acetylamino)-3-phenyl-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-Boc-Sar-Phe-OMe (138172-28-8) → (S)-2-(2-Methylamino-acetylamino)-3-phenyl-propionic acid methyl ester (119767-54-3)

Guidance literature:

With methoxybenzene; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmc.2006.04.031

Reference yield:

(S)-2-(2-Methylamino-acetylamino)-3-phenyl-propionic acid methyl ester (119767-54-3) → (3S,6S,9S,12S)-12-Benzyl-6,9-diisobutyl-3-isopropyl-1-methyl-1,4,7,10,13-pentaaza-cyclopentadecane-2,5,8,11,14-pentaone

Guidance literature:

Multi-step reaction with 5 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*BF₄^(1-); diisopropylethylamine / CH₂Cl₂ / 20 °C

2: trifluoroacetic acid; anisole / CH₂Cl₂

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*BF₄^(1-); diisopropylethylamine / acetonitrile / 20 °C

4: anisole; HCl / tetrahydrofuran / 96 h / 20 °C

5: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium*BF₄^(1-); 3-(Diethoxy-phosphoryloxy)-3H-benzo[d][1,2,3]triazin-4-one; O-(7-azabenzotriazol-1-yl)-N,N,N',N'-(CH₃)4uronium*PF₆^(1-) / diisopropylethylamine / acetonitrile; tetrahydrofuran; CH₂Cl₂ / 2 h / 20 °C

With hydrogenchloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1016/j.bmc.2006.04.031

Reference yield:

(S)-2-(2-Methylamino-acetylamino)-3-phenyl-propionic acid methyl ester (119767-54-3) + t-Boc-L-valine (13734-41-3) → (S)-2-{2-[((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-methyl-amino]-acetylamino}-3-phenyl-propionic acid methyl ester (863781-60-6)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/ol051161g

upstream raw materials:

N-Boc-Sar-Phe-OMe

Downstream raw materials:

(S)-2-{2-[((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-methyl-amino]-acetylamino}-3-phenyl-propionic acid methyl ester

(S)-2-[2-({(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyryl}-methyl-amino)-acetylamino]-3-phenyl-propionic acid methyl ester