1-(4-Chloroanilino)-4-methyl-5-phenyl-2-[(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)sulfanyl]imidazole-2(3H)-thione

Base Information

• Chemical Name: 1-(4-Chloroanilino)-4-methyl-5-phenyl-2-[(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)sulfanyl]imidazole-2(3H)-thione
• CAS No.: 302919-25-1
• Molecular Formula: C₄₂H₃₄ClN₃O₇S
• Molecular Weight: 760.267
• Mol file: 302919-25-1.mol

Synonyms:1-(4-Chloroanilino)-4-methyl-5-phenyl-2-[(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)sulfanyl]imidazole-2(3H)-thione

Chemical Property of 1-(4-Chloroanilino)-4-methyl-5-phenyl-2-[(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)sulfanyl]imidazole-2(3H)-thione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-Chloroanilino)-4-methyl-5-phenyl-2-[(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)sulfanyl]imidazole-2(3H)-thione

There total 2 articles about 1-(4-Chloroanilino)-4-methyl-5-phenyl-2-[(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)sulfanyl]imidazole-2(3H)-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose (6974-32-9) + 1-(4-Chloroanilino)-4-methyl-5-phenylimidazole-2(3H)-thione (191349-41-4) → 1-(4-Chloroanilino)-4-methyl-5-phenyl-2-[(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)sulfanyl]imidazole-2(3H)-thione (302919-25-1)

Guidance literature:

1-(4-Chloroanilino)-4-methyl-5-phenylimidazole-2(3H)-thione; With 1,1,1,3,3,3-hexamethyl-disilazane; In acetonitrile; for 16h; Heating;

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose; With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 20 - 75 ℃;

DOI:10.1081/NCN-120021429

Reference yield:

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose (6974-32-9) + 1-(4-Chloroanilino)-4-methyl-5-phenylimidazole-2(3H)-thione (191349-41-4) → 2-[(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)sulfanyl]-1-(4'-chlorophenylamino)-4-methyl-5-phenyl-1H-imidazole (302919-22-8) + 1-(4-Chloroanilino)-4-methyl-5-phenyl-2-[(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)sulfanyl]imidazole-2(3H)-thione (302919-25-1)

Guidance literature:

With N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 40 ℃; for 4h; Further Variations:; Solvents; Temperatures; Product distribution;

DOI:10.1135/cccc20001145

Reference yield: 95.0%

1-(4-Chloroanilino)-4-methyl-5-phenyl-2-[(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)sulfanyl]imidazole-2(3H)-thione (302919-25-1) → 1-(4'-chlorophenylamino)-4-methyl-5-phenyl-3-(β-D-ribofuranosyl)-1H-imidazole-2-thione

Guidance literature:

With ammonia; In methanol; at 20 ℃;

DOI:10.1135/cccc20001145

upstream raw materials:

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

1-(4-Chloroanilino)-4-methyl-5-phenylimidazole-2(3H)-thione