ethyl-2-formyl-2-methylbutanoate

Base Information

• Chemical Name: ethyl-2-formyl-2-methylbutanoate
• CAS No.: 188026-75-7
• Molecular Formula: C₈H₁₄O₃
• Molecular Weight: 158.197
• Mol file: 188026-75-7.mol

Synonyms:ethyl-2-formyl-2-methylbutanoate

Chemical Property of ethyl-2-formyl-2-methylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of ethyl-2-formyl-2-methylbutanoate

There total 2 articles about ethyl-2-formyl-2-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-pentyl α-methyldiazoacetate (1401455-74-0) + propionaldehyde (123-38-6) → (S)-pentan-3-yl 2-methyl-3-oxopentanoate (137708-19-1) + ethyl-2-formyl-2-methylbutanoate (188026-75-7)

Guidance literature:

With C₃H₄F₅NO₄S₂*C₃₁H₃₂BNO; In toluene; at -95 ℃; for 1h; stereoselective reaction; Inert atmosphere;

DOI:10.1002/anie.201204350

Reference yield: 89.0%

benzyl 2-diazopropanoate (55895-92-6) + propionaldehyde (123-38-6) → (R)-benzyl 2-methyl-3-oxopentanoate (1401455-67-1) + ethyl-2-formyl-2-methylbutanoate (188026-75-7)

Guidance literature:

With C₂HF₆NO₄S₂*C₃₁H₃₂BNO; In toluene; at -95 ℃; for 0.5h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201204350

Reference yield:

3-phenyl-propionaldehyde (104-53-0) + ethyl-2-formyl-2-methylbutanoate (188026-75-7) → (3S,4S,5S)-3-Ethyl-4-hydroxy-3-methyl-5-phenethyl-dihydro-furan-2-one + (3S,4R,5R)-3-Ethyl-4-hydroxy-3-methyl-5-phenethyl-dihydro-furan-2-one + (2S,3S,4S)-2-Ethyl-3,4-dihydroxy-2-methyl-6-phenyl-hexanoic acid ethyl ester + (2S,3R,4R)-2-Ethyl-3,4-dihydroxy-2-methyl-6-phenyl-hexanoic acid ethyl ester

Guidance literature:

Vanadium (III) chloride-(tris-tetrahydrofuran); zinc; In dichloromethane; for 48h; Title compound not separated from byproducts;

DOI:10.1055/s-1997-709

upstream raw materials:

3-pentyl α-methyldiazoacetate

propionaldehyde

benzyl 2-diazopropanoate

Refernces