(S)-9-(tert-Butyl-diphenyl-silanyloxy)-1-(tetrahydro-pyran-2-yloxy)-non-4-yn-2-ol

Base Information

Chemical Name:(S)-9-(tert-Butyl-diphenyl-silanyloxy)-1-(tetrahydro-pyran-2-yloxy)-non-4-yn-2-ol
CAS No.:182247-34-3
Molecular Formula:C₃₀H₄₂O₄Si
Molecular Weight:494.747
Hs Code.:

Synonyms:(S)-9-(tert-Butyl-diphenyl-silanyloxy)-1-(tetrahydro-pyran-2-yloxy)-non-4-yn-2-ol

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Chemical Property of (S)-9-(tert-Butyl-diphenyl-silanyloxy)-1-(tetrahydro-pyran-2-yloxy)-non-4-yn-2-ol

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Technology Process of (S)-9-(tert-Butyl-diphenyl-silanyloxy)-1-(tetrahydro-pyran-2-yloxy)-non-4-yn-2-ol

There total 1 articles about (S)-9-(tert-Butyl-diphenyl-silanyloxy)-1-(tetrahydro-pyran-2-yloxy)-non-4-yn-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 128217-23-2
1-(tert-butyldiphenylsilyloxy)-5-hexyne

: 110657-96-0
2-((R)-oxiran-2-ylmethoxy)tetrahydro-2H-pyran

: 182247-34-3
(S)-9-(tert-Butyl-diphenyl-silanyloxy)-1-(tetrahydro-pyran-2-yloxy)-non-4-yn-2-ol

Guidance literature:: With n-butyllithium; boron trifluoride diethyl etherate; Yield given. Multistep reaction; 2) THF, -78 deg C;
DOI:10.1016/0040-4039(96)01339-1

Reference yield: 93.0%

: 182247-34-3
(S)-9-(tert-Butyl-diphenyl-silanyloxy)-1-(tetrahydro-pyran-2-yloxy)-non-4-yn-2-ol

: 182247-36-5
(Z)-(S)-9-(tert-Butyl-diphenyl-silanyloxy)-1-(tetrahydro-pyran-2-yloxy)-non-4-en-2-ol

Guidance literature:: With quinoline; hydrogen; Pd-BaSO₄;
DOI:10.1016/0040-4039(96)01339-1

Reference yield:

: 182247-34-3
(S)-9-(tert-Butyl-diphenyl-silanyloxy)-1-(tetrahydro-pyran-2-yloxy)-non-4-yn-2-ol

: tert-Butyl-diphenyl-[(5R,6S,8S)-5,6,8-tris-benzyloxy-9-(tetrahydro-pyran-2-yloxy)-nonyloxy]-silane

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / hydrogen, quinoline / Pd/BaSO₄

2: OsO₄, DHQD-IND, K₃Fe(CN)6, K₂CO₃ / 2-methyl-propan-2-ol

3: 81 percent / NaH, n-Bu₄NI / tetrahydrofuran / Heating

With quinoline; osmium(VIII) oxide; DHQD-IND; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; potassium hexacyanoferrate(III); Pd-BaSO₄; In tetrahydrofuran; tert-butyl alcohol;
DOI:10.1016/0040-4039(96)01339-1