N-Pyridin-3-yl-cyclohexanecarboximidothioic acid pyridin-2-yl ester

Base Information

• Chemical Name: N-Pyridin-3-yl-cyclohexanecarboximidothioic acid pyridin-2-yl ester
• CAS No.: 119541-42-3
• Molecular Formula: C₁₇H₁₉N₃S
• Molecular Weight: 297.424
• Mol file: 119541-42-3.mol

Synonyms:N-Pyridin-3-yl-cyclohexanecarboximidothioic acid pyridin-2-yl ester

Chemical Property of N-Pyridin-3-yl-cyclohexanecarboximidothioic acid pyridin-2-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Pyridin-3-yl-cyclohexanecarboximidothioic acid pyridin-2-yl ester

There total 2 articles about N-Pyridin-3-yl-cyclohexanecarboximidothioic acid pyridin-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

Cyclohexanecarboxylic acid 2-thioxo-2H-pyridin-1-yl ester (105398-69-4) + 3-pyridyl isocyanide (85526-38-1) → N-Pyridin-3-yl-cyclohexanecarboximidothioic acid pyridin-2-yl ester (119541-42-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at -15 ℃; for 0.416667h; Irradiation;

DOI:10.1016/S0040-4020(01)85980-9

Reference yield:

pyridin-3-ylamine (462-08-8) → N-Pyridin-3-yl-cyclohexanecarboximidothioic acid pyridin-2-yl ester (119541-42-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 30 percent / 50percent aq. NaOH / n-Bu₄NHSO₄ / CH₂Cl₂; CHCl₃ / 12 h

2: 70 percent / trifluoroacetic acid / CH₂Cl₂ / 0.42 h / -15 °C / Irradiation

With sodium hydroxide; trifluoroacetic acid; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; chloroform;

DOI:10.1016/S0040-4020(01)85980-9

Reference yield: 95.0%

N-Pyridin-3-yl-cyclohexanecarboximidothioic acid pyridin-2-yl ester (119541-42-3) → N-(pyridin-3-yl)cyclohexanecarboxamide (119520-52-4)

Guidance literature:

With water; In 1,4-dioxane; for 12h; Ambient temperature;

DOI:10.1016/S0040-4020(01)85980-9

upstream raw materials:

Cyclohexanecarboxylic acid 2-thioxo-2H-pyridin-1-yl ester

3-pyridyl isocyanide

pyridin-3-ylamine

Downstream raw materials:

N-(pyridin-3-yl)cyclohexanecarboxamide

Cyclohexanecarboxylic acid 2-thioxo-2H-pyridin-1-yl ester

cyclohexanylcarbonyl chloride

Cyclohexanecarboxylic acid