ethyl 2-methyl-2-{2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}propanoate

Base Information

Chemical Name:ethyl 2-methyl-2-{2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}propanoate
CAS No.:1076219-12-9
Molecular Formula:C₂₁H₂₀F₃NO₃
Molecular Weight:391.39
Hs Code.:

Synonyms:ethyl 2-methyl-2-{2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}propanoate

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Chemical Property of ethyl 2-methyl-2-{2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}propanoate

Chemical Property:

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Technology Process of ethyl 2-methyl-2-{2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}propanoate

There total 3 articles about ethyl 2-methyl-2-{2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85013-98-5
1-[4-(trifluoromethoxy)phenyl]ethan-1-one

: 192643-90-6
ethyl 2-(4-hydrazinophenyl)-2-methylpropanoate

: 1076219-12-9
ethyl 2-methyl-2-{2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}propanoate

Guidance literature:: With acetic acid; zinc(II) chloride; In ethanol;
DOI:10.1016/j.bmcl.2010.11.067

Reference yield:

: 83397-45-9
ethyl 2-methyl-2-(4-nitrophenyl)propanoate

: 1076219-12-9
ethyl 2-methyl-2-{2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 10% palladium on activated carbon / ethanol

2: hydrogenchloride; tin(II) chloride dihdyrate; sodium nitrite

3: acetic acid; zinc(II) chloride / ethanol

With hydrogenchloride; tin(II) chloride dihdyrate; 10% palladium on activated carbon; acetic acid; zinc(II) chloride; sodium nitrite; In ethanol;
DOI:10.1016/j.bmcl.2010.11.067

Reference yield:

: 36924-81-9
ethyl 2-(4-aminophenyl)-2-methylpropanoate

: 1076219-12-9
ethyl 2-methyl-2-{2-[4-(trifluoromethoxy)phenyl]-1H-indol-5-yl}propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; tin(II) chloride dihdyrate; sodium nitrite

2: acetic acid; zinc(II) chloride / ethanol

With hydrogenchloride; tin(II) chloride dihdyrate; acetic acid; zinc(II) chloride; sodium nitrite; In ethanol;
DOI:10.1016/j.bmcl.2010.11.067