2-butyl-6-chloro-4-hydroxymethyl-5-methyl-3-<(2'-cyanobiphenyl-4-yl)methyl>pyridine

Base Information

Chemical Name:2-butyl-6-chloro-4-hydroxymethyl-5-methyl-3-<(2'-cyanobiphenyl-4-yl)methyl>pyridine
CAS No.:168072-31-9
Molecular Formula:C₂₅H₂₅ClN₂O
Molecular Weight:404.939
Hs Code.:

Synonyms:2-butyl-6-chloro-4-hydroxymethyl-5-methyl-3-<(2'-cyanobiphenyl-4-yl)methyl>pyridine

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Chemical Property of 2-butyl-6-chloro-4-hydroxymethyl-5-methyl-3-<(2'-cyanobiphenyl-4-yl)methyl>pyridine

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Technology Process of 2-butyl-6-chloro-4-hydroxymethyl-5-methyl-3-<(2'-cyanobiphenyl-4-yl)methyl>pyridine

There total 18 articles about 2-butyl-6-chloro-4-hydroxymethyl-5-methyl-3-<(2'-cyanobiphenyl-4-yl)methyl>pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.1%

: 168072-30-8
4-acetoxymethyl-2-butyl-6-chloro-5-methyl-3-<(2'-cyanobiphenyl-4-yl)methyl>pyridine

: 168072-31-9
2-butyl-6-chloro-4-hydroxymethyl-5-methyl-3-<(2'-cyanobiphenyl-4-yl)methyl>pyridine

Guidance literature:: With potassium carbonate; In methanol; for 1.5h;
DOI:10.1248/cpb.42.1841

Reference yield:

: 57598-33-1
2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

: 168072-31-9
2-butyl-6-chloro-4-hydroxymethyl-5-methyl-3-<(2'-cyanobiphenyl-4-yl)methyl>pyridine

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) Mg / 1.) THF, 20 deg C, 2.) THF, 20 deg C, 2 h

2: 1.) Mg / 1.) THF, 2.) THF, -78 deg C, 1.5 h

3: SOCl₂ / 0.5 h / 60 °C

4: Zn, AcOH / 0.58 h / Ambient temperature

5: 93.1 percent / POCl₃, pyridine / 3 h / 100 °C

6: 73.7 percent / m-chloroperoxybenzoic acid / CHCl₃ / 4 h / Ambient temperature

7: 44.3 percent / AcOH / 2 h / 120 °C

8: 94.1 percent / 10percent aq. K₂CO₃ / methanol / 1.5 h

With pyridine; thionyl chloride; potassium carbonate; magnesium; acetic acid; 3-chloro-benzenecarboperoxoic acid; zinc; trichlorophosphate; In methanol; chloroform;
DOI:10.1248/cpb.42.1841

Reference yield:

: 1115-11-3
2-methyl-2-pentenal

: 168072-31-9
2-butyl-6-chloro-4-hydroxymethyl-5-methyl-3-<(2'-cyanobiphenyl-4-yl)methyl>pyridine

Guidance literature:: Multi-step reaction with 13 steps

1: piperidine / ethanol / 3 h / Heating

2: 1 N aq. (NH₄)2Ce(NO₃)6 / acetone / 0.33 h / 0 °C

3: 98.3 percent / m-chloroperoxybenzoic acid / CHCl₃ / 4 h / Ambient temperature

4: POCl₃ / 2 h / Heating

5: LiAlH₄ / tetrahydrofuran / 2 h / 20 °C

6: MnO₂ / CHCl₃ / 5 h / Heating

7: 1.) Mg / 1.) THF, 2.) THF, -78 deg C, 1.5 h

8: SOCl₂ / 0.5 h / 60 °C

9: Zn, AcOH / 0.58 h / Ambient temperature

10: 93.1 percent / POCl₃, pyridine / 3 h / 100 °C

11: 73.7 percent / m-chloroperoxybenzoic acid / CHCl₃ / 4 h / Ambient temperature

12: 44.3 percent / AcOH / 2 h / 120 °C

13: 94.1 percent / 10percent aq. K₂CO₃ / methanol / 1.5 h

With piperidine; pyridine; manganese(IV) oxide; lithium aluminium tetrahydride; thionyl chloride; ammonium cerium(IV) nitrate; potassium carbonate; magnesium; acetic acid; 3-chloro-benzenecarboperoxoic acid; zinc; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; chloroform; acetone;
DOI:10.1248/cpb.42.1841