4-(4-(allyl(methyl)amino)-8-(4-fluorophenyl)-6-methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-ylamino)-2-(allyloxy)benzonitrile trifluoroacetate

Base Information

Chemical Name:4-(4-(allyl(methyl)amino)-8-(4-fluorophenyl)-6-methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-ylamino)-2-(allyloxy)benzonitrile trifluoroacetate
CAS No.:1356010-68-8
Molecular Formula:C₂HF₃O₂*C₂₈H₂₉FN₆O
Molecular Weight:598.6
Hs Code.:

4-(4-(allyl(methyl)amino)-8-(4-fluorophenyl)-6-methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-ylamino)-2-(allyloxy)benzonitrile trifluoroacetate

Synonyms:4-(4-(allyl(methyl)amino)-8-(4-fluorophenyl)-6-methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-ylamino)-2-(allyloxy)benzonitrile trifluoroacetate

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Chemical Property of 4-(4-(allyl(methyl)amino)-8-(4-fluorophenyl)-6-methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-ylamino)-2-(allyloxy)benzonitrile trifluoroacetate

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Technology Process of 4-(4-(allyl(methyl)amino)-8-(4-fluorophenyl)-6-methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-ylamino)-2-(allyloxy)benzonitrile trifluoroacetate

There total 11 articles about 4-(4-(allyl(methyl)amino)-8-(4-fluorophenyl)-6-methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-ylamino)-2-(allyloxy)benzonitrile trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.98%

: 757247-69-1
2-(allyloxy)-4-aminobenzonitrile

: 1356010-09-7
N-allyl-2-chloro-8-(4-fluorophenyl)-N,6-dimethyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-amine

: 1356010-68-8
4-(4-(allyl(methyl)amino)-8-(4-fluorophenyl)-6-methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-ylamino)-2-(allyloxy)benzonitrile trifluoroacetate

Guidance literature:: With sulfuric acid; In 1-methyl-pyrrolidin-2-one; at 90 ℃;

Reference yield:

: 459-22-3
4-fluorophenylacetonitrile

: 1356010-68-8
4-(4-(allyl(methyl)amino)-8-(4-fluorophenyl)-6-methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-ylamino)-2-(allyloxy)benzonitrile trifluoroacetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / -10 °C

1.2: 40 °C

2.1: hydrogen; sulfuric acid / palladium 10% on activated carbon / acetic acid / 18 h / 20 °C

3.1: ethanol / 18 h / 20 °C

4.1: potassium carbonate / acetone / 2 h / 0 - 20 °C

5.1: potassium tert-butylate / tetrahydrofuran / 2 h / 20 °C

6.1: potassium tert-butylate / ethanol / 36 h / Reflux

7.1: trichlorophosphate / N,N-dimethyl-formamide / 10 h / Reflux

8.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 20 °C

9.1: sulfuric acid / 1-methyl-pyrrolidin-2-one / 90 °C

With sulfuric acid; potassium tert-butylate; hydrogen; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; acetic acid; acetone;

Reference yield:

: 7054-58-2,15032-42-5
ethyl 2-cyano-2-(4-fluorophenyl)acetate

: 1356010-68-8
4-(4-(allyl(methyl)amino)-8-(4-fluorophenyl)-6-methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-ylamino)-2-(allyloxy)benzonitrile trifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1: hydrogen; sulfuric acid / palladium 10% on activated carbon / acetic acid / 18 h / 20 °C

2: ethanol / 18 h / 20 °C

3: potassium carbonate / acetone / 2 h / 0 - 20 °C

4: potassium tert-butylate / tetrahydrofuran / 2 h / 20 °C

5: potassium tert-butylate / ethanol / 36 h / Reflux

6: trichlorophosphate / N,N-dimethyl-formamide / 10 h / Reflux

7: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 20 °C

8: sulfuric acid / 1-methyl-pyrrolidin-2-one / 90 °C

With sulfuric acid; potassium tert-butylate; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; acetic acid; acetone;