3-Phenyl-5,6-dihydro-6-oxopyridazine-1(4H)-acetic acid

Base Information

Chemical Name:3-Phenyl-5,6-dihydro-6-oxopyridazine-1(4H)-acetic acid
CAS No.:127806-49-9
Molecular Formula:C₁₂H₁₂N₂O₃
Molecular Weight:232.239
Hs Code.:
DSSTox Substance ID:DTXSID801211672
Nikkaji Number:J357.754F

Synonyms:DTXSID801211672;AKOS015935660;EU-0063382;SR-01000102617;SR-01000102617-1;3-Phenyl-5,6-dihydro-6-oxopyridazine-1(4H)-acetic acid;5,6-Dihydro-6-oxo-3-phenyl-1(4H)-pyridazineacetic acid;127806-49-9

Suppliers and Price of 3-Phenyl-5,6-dihydro-6-oxopyridazine-1(4H)-acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Phenyl-5,6-dihydro-6-oxopyridazine-1(4H)-acetic acid

Chemical Property:

XLogP3:0.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:232.08479225
Heavy Atom Count:17
Complexity:346

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC(=O)N(N=C1C2=CC=CC=C2)CC(=O)O

Technology Process of 3-Phenyl-5,6-dihydro-6-oxopyridazine-1(4H)-acetic acid

There total 4 articles about 3-Phenyl-5,6-dihydro-6-oxopyridazine-1(4H)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 142731-38-2
(6-Oxo-3-phenyl-5,6-dihydro-4H-pyridazin-1-yl)-acetic acid methyl ester

: 127806-49-9
2-Carboxymethyl-4-phenyl-1,2,5,6-tetrahydro-1-oxo-pyridazine

Guidance literature:: With lithium hydroxide; In methanol; Ambient temperature;

Reference yield: 63.0%

: 127806-52-4
2-Carbethoxymethyl-4-phenyl-1,2,5,6-tetrahydro-1-oxo-pyridazine

: 127806-49-9
2-Carboxymethyl-4-phenyl-1,2,5,6-tetrahydro-1-oxo-pyridazine

Guidance literature:: With sodium hydroxide; for 4.5h; Heating;

Reference yield:

: 2051-95-8
succinylbenzene

: 127806-49-9
2-Carboxymethyl-4-phenyl-1,2,5,6-tetrahydro-1-oxo-pyridazine

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / hydrazine hydrate / ethanol / 17 h / Heating

2: 1) NaH / 1) THF, room temp., 30 min; 2) THF, room temp., 17 h

3: 83 percent / aqueous LiOH / methanol / Ambient temperature

With lithium hydroxide; sodium hydride; hydrazine hydrate; In methanol; ethanol;