6-<2-chloro-4-(3-carboxypropyl)phenyl>-3-cyclopropanecarbonyl-8,11-dimethyl-2,3,4,5,-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine

Base Information

Chemical Name:6-<2-chloro-4-(3-carboxypropyl)phenyl>-3-cyclopropanecarbonyl-8,11-dimethyl-2,3,4,5,-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine
CAS No.:141783-07-5
Molecular Formula:C₂₆H₂₆ClN₅O₃S
Molecular Weight:524.043
Hs Code.:

6-<2-chloro-4-(3-carboxypropyl)phenyl>-3-cyclopropanecarbonyl-8,11-dimethyl-2,3,4,5,-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine

Synonyms:6-<2-chloro-4-(3-carboxypropyl)phenyl>-3-cyclopropanecarbonyl-8,11-dimethyl-2,3,4,5,-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine

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Chemical Property of 6-<2-chloro-4-(3-carboxypropyl)phenyl>-3-cyclopropanecarbonyl-8,11-dimethyl-2,3,4,5,-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine

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Technology Process of 6-<2-chloro-4-(3-carboxypropyl)phenyl>-3-cyclopropanecarbonyl-8,11-dimethyl-2,3,4,5,-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine

There total 22 articles about 6-<2-chloro-4-(3-carboxypropyl)phenyl>-3-cyclopropanecarbonyl-8,11-dimethyl-2,3,4,5,-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 141783-08-6
C₃₉H₃₆ClN₅O₃S

: 141783-07-5
6-<2-chloro-4-(3-carboxypropyl)phenyl>-3-cyclopropanecarbonyl-8,11-dimethyl-2,3,4,5,-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine

Guidance literature:: With trifluoroacetic acid; In chloroform; at 0 ℃; for 0.5h;
DOI:10.1248/cpb.40.762

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 141783-07-5
6-<2-chloro-4-(3-carboxypropyl)phenyl>-3-cyclopropanecarbonyl-8,11-dimethyl-2,3,4,5,-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine

Guidance literature:: Multi-step reaction with 17 steps

1: 0.5 h / 110 °C

2: 1.) DMSO, oxalyl chloride, 2.) Et₃N / 1.) CH₂Cl₂, from -70 deg C to -50 deg C, 30 min, 2.) CH₂Cl₂, from -50 deg C to RT

3: 72 percent / Et₃N, sulfur / dimethylformamide / 1 h / 50 °C

4: 247 g / CHCl₃ / Ambient temperature

5: 290 g / pyridine, AcOH / toluene / 1.5 h / Heating

6: 199 g / NaOH / ethanol / 1.5 h / Ambient temperature

7: Et₃N / toluene / Heating

8: 70 percent / Lawesson's reagent / 1,2-dimethoxy-ethane / 1.5 h / 80 °C

9: 37 percent / dioxane / 2 h / 130 °C

10: 58 percent / TFA / CHCl₃ / 0 °C

11: pyridinium dichromate (PDC) / dimethylformamide / 15 h / Ambient temperature

12: CHCl₃

13: 8N NaOH / methanol / Heating

14: pyridine / CH₂Cl₂ / 0 °C

15: 31 percent / CHCl₃ / Ambient temperature

17: 100 percent / TFA / CHCl₃ / 0.5 h / 0 °C

With Lawessons reagent; pyridine; sodium hydroxide; dipyridinium dichromate; oxalyl dichloride; sulfur; acetic acid; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.40.762

Reference yield:

: 141733-73-5
2-chloro-4-(3-hydroxypropyl)benzonitrile

: 141783-07-5
6-<2-chloro-4-(3-carboxypropyl)phenyl>-3-cyclopropanecarbonyl-8,11-dimethyl-2,3,4,5,-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine

Guidance literature:: Multi-step reaction with 18 steps

1: 73 percent / diisopropylethylamine / CH₂Cl₂ / Ambient temperature

2: 1.) LDA / 1.) THF, -70deg C, 30 min, 2.) THF, -70 deg C, 30 min

3: conc. HCl / methanol / 0.25 h / 50 °C

4: 72 percent / Et₃N, sulfur / dimethylformamide / 1 h / 50 °C

5: 247 g / CHCl₃ / Ambient temperature

6: 290 g / pyridine, AcOH / toluene / 1.5 h / Heating

7: 199 g / NaOH / ethanol / 1.5 h / Ambient temperature

8: Et₃N / toluene / Heating

9: 70 percent / Lawesson's reagent / 1,2-dimethoxy-ethane / 1.5 h / 80 °C

10: 37 percent / dioxane / 2 h / 130 °C

11: 58 percent / TFA / CHCl₃ / 0 °C

12: pyridinium dichromate (PDC) / dimethylformamide / 15 h / Ambient temperature

13: CHCl₃

14: 8N NaOH / methanol / Heating

15: pyridine / CH₂Cl₂ / 0 °C

16: 31 percent / CHCl₃ / Ambient temperature

18: 100 percent / TFA / CHCl₃ / 0.5 h / 0 °C

With Lawessons reagent; pyridine; hydrogenchloride; sodium hydroxide; dipyridinium dichromate; sulfur; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium diisopropyl amide; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.40.762