4-(4-(2-(2-propylpyridin-4-yl)thiazol-4-yl)phenylamino)-N-isopropylbutanamide

Base Information

Chemical Name:4-(4-(2-(2-propylpyridin-4-yl)thiazol-4-yl)phenylamino)-N-isopropylbutanamide
CAS No.:1046045-82-2
Molecular Formula:C₂₄H₃₀N₄OS
Molecular Weight:422.594
Hs Code.:

Synonyms:4-(4-(2-(2-propylpyridin-4-yl)thiazol-4-yl)phenylamino)-N-isopropylbutanamide

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Chemical Property of 4-(4-(2-(2-propylpyridin-4-yl)thiazol-4-yl)phenylamino)-N-isopropylbutanamide

Chemical Property:

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Technology Process of 4-(4-(2-(2-propylpyridin-4-yl)thiazol-4-yl)phenylamino)-N-isopropylbutanamide

There total 5 articles about 4-(4-(2-(2-propylpyridin-4-yl)thiazol-4-yl)phenylamino)-N-isopropylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1046045-83-3
C₂₉H₃₈N₄O₃S

: 1046045-82-2
4-(4-(2-(2-propylpyridin-4-yl)thiazol-4-yl)phenylamino)-N-isopropylbutanamide

Guidance literature:: With trifluoroacetic acid; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

: 125256-03-3
4-(4-(4-bromophenyl)thiazol-2-yl)-2-propylpyridine

: 1046045-82-2
4-(4-(2-(2-propylpyridin-4-yl)thiazol-4-yl)phenylamino)-N-isopropylbutanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis(diphenylphosphino)biphenyl / toluene / 20 h / 100 °C / Sealed tube

2.1: hydrogenchloride / tetrahydrofuran; water / 2 h / 20 °C

3.1: dmap / tetrahydrofuran / 17 h

4.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 20 °C

4.2: 18 h

5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 18 h / 20 °C

6.1: triethylamine; HATU / N,N-dimethyl-formamide / 18 h

7.1: trifluoroacetic acid / tetrahydrofuran / 18 h / 20 °C

With hydrogenchloride; dmap; sodium hydroxide; water; sodium hydride; triethylamine; HATU; trifluoroacetic acid; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis(diphenylphosphino)biphenyl; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1046045-73-1
tert-butyl 4-(2-(2-propylpyridin-4-yl)thiazol-4-yl)phenylcarbamate

: 1046045-82-2
4-(4-(2-(2-propylpyridin-4-yl)thiazol-4-yl)phenylamino)-N-isopropylbutanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 20 °C

1.2: 18 h

2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 18 h / 20 °C

3.1: triethylamine; HATU / N,N-dimethyl-formamide / 18 h

4.1: trifluoroacetic acid / tetrahydrofuran / 18 h / 20 °C

With sodium hydroxide; water; sodium hydride; triethylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;