2-((1-methylpiperidin-4-yl)amino)-4-(m-tolylamino)pyrido[4,3-d]pyrimidin-5(6H)-one

Base Information

Chemical Name:2-((1-methylpiperidin-4-yl)amino)-4-(m-tolylamino)pyrido[4,3-d]pyrimidin-5(6H)-one
CAS No.:1208169-75-8
Molecular Formula:C₂₀H₂₄N₆O
Molecular Weight:364.45
Hs Code.:

Synonyms:2-((1-methylpiperidin-4-yl)amino)-4-(m-tolylamino)pyrido[4,3-d]pyrimidin-5(6H)-one

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Chemical Property of 2-((1-methylpiperidin-4-yl)amino)-4-(m-tolylamino)pyrido[4,3-d]pyrimidin-5(6H)-one

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Technology Process of 2-((1-methylpiperidin-4-yl)amino)-4-(m-tolylamino)pyrido[4,3-d]pyrimidin-5(6H)-one

There total 12 articles about 2-((1-methylpiperidin-4-yl)amino)-4-(m-tolylamino)pyrido[4,3-d]pyrimidin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 41838-46-4
4-Amino-1-methylpiperidine

: 1208170-04-0
4-[(3-methylphenyl)amino]-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one

: 1208169-75-8
2-((1-methylpiperidin-4-yl)amino)-4-(m-tolylamino)pyrido[4,3-d]pyrimidin-5(6H)-one

Guidance literature:: 4-[(3-methylphenyl)amino]-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one; With 3-chloro-benzenecarboperoxoic acid; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

4-Amino-1-methylpiperidine; In N,N-dimethyl-formamide; for 18h;
DOI:10.1016/j.tetlet.2019.151312

Reference yield:

: 1208170-17-5
4-chloro-6-methyl-2-(methylthio)-pyrimidine-5-carbonitrile

: 1208169-75-8
2-((1-methylpiperidin-4-yl)amino)-4-(m-tolylamino)pyrido[4,3-d]pyrimidin-5(6H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1.5 h / 75 °C

2.1: N,N-dimethyl-formamide / 1.5 h / 110 °C

3.1: acetic acid; hydrogen bromide / 0.33 h / 20 °C

4.1: acetic acid; hydrogenchloride; water / 1.5 h / 80 °C

5.1: 3-chloro-benzenecarboperoxoic acid / N,N-dimethyl-formamide / 4 h / 20 °C

5.2: 18 h

With hydrogenchloride; water; hydrogen bromide; acetic acid; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2019.151312

Reference yield:

: 5417-82-3
(1-ethoxyethylidene)malononitrile

: 1208169-75-8
2-((1-methylpiperidin-4-yl)amino)-4-(m-tolylamino)pyrido[4,3-d]pyrimidin-5(6H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium methylate / methanol / 0 - 20 °C

2.1: magnesium sulfate; copper dichloride; tert.-butylnitrite / acetonitrile / 3 h / 80 °C

3.1: N,N-dimethyl-formamide / 1.5 h / 20 °C

4.1: N,N-dimethyl-formamide / 1 h / 110 °C

5.1: acetic acid; hydrogen bromide; water / 1.5 h / 83 °C

6.1: hydrogenchloride / isopropyl alcohol; water / 24 h / Reflux

7.1: 3-chloro-benzenecarboperoxoic acid / N,N-dimethyl-formamide / 4 h / 20 °C

7.2: 18 h

With hydrogenchloride; tert.-butylnitrite; water; hydrogen bromide; sodium methylate; magnesium sulfate; acetic acid; 3-chloro-benzenecarboperoxoic acid; copper dichloride; In methanol; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
DOI:10.1016/j.tetlet.2019.151312