pFHHSiD

Base Information

Chemical Name:pFHHSiD
CAS No.:116679-83-5
Molecular Formula:C20H32 F N O Si
Molecular Weight:349.564
Hs Code.:
UNII:XEO1GM7K2V
DSSTox Substance ID:DTXSID60922113
Nikkaji Number:J292.875B
Wikidata:Q27078090
Pharos Ligand ID:FXMQ32CPBFX4
ChEMBL ID:CHEMBL1256682
Mol file:116679-83-5.mol

Synonyms:4-fluorohexahydrosiladifenidol;4-fluorohexahydrosiladifenidol, (+-)-isomer;FHHSiD;p-F-HHSiD;p-fluoro-hexahydro-sila-difenidol;p-fluoro-hexahydro-sila-diphenidol;p-fluorohexahydrosiladyphenidol;pFHHSiD

Suppliers and Price of pFHHSiD

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
p-Fluorohexahydro-sila-difenidol
25mg
$ 390.00

Sigma-Aldrich
p-Fluorohexahydro-sila-difenidol hydrochloride powder, ≥98% (HPLC)
50mg
$ 1120.00

Sigma-Aldrich
p-Fluorohexahydro-sila-difenidol hydrochloride powder, ≥98% (HPLC)
10mg
$ 279.00

Total 2 raw suppliers

Chemical Property of pFHHSiD

Chemical Property:

Vapor Pressure:8.59E-09mmHg at 25°C
Boiling Point:447.5°Cat760mmHg
PKA:13.74±0.20(Predicted)
Flash Point:224.4°C
PSA：23.47000
Density:1.07g/cm³
LogP:4.92070
Solubility.:H2O: 1.5 mg/mL, slightly soluble
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:349.22371934
Heavy Atom Count:24
Complexity:363

Purity/Quality:

95% ^*data from raw suppliers

p-Fluorohexahydro-sila-difenidol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC(CC1)[Si](CCCN2CCCCC2)(C3=CC=C(C=C3)F)O
Uses p-Fluorohexahydro-sila-difenidol is a high affinity M3 muscarinic acetylcholine receptor antagonist.

Technology Process of pFHHSiD

There total 11 articles about pFHHSiD which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-89-4
piperidine

: 116679-83-5
p-fluorohexahydro-sila-difenidol

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / methanol / 16 h / Heating

2: 1.) n-BuLi / 1.) Et₂O, hexane, -35 deg C, 2 h, 2.) Et₂O, RT, 16 h

3: 82 percent / LiAlH₄ / dibutyl ether / 16 h / Heating

4: KOH / ethanol; H₂O / 24 h / Ambient temperature

With potassium hydroxide; lithium aluminium tetrahydride; n-butyllithium; In methanol; ethanol; dibutyl ether; water;
DOI:10.1016/0022-328X(91)80194-O

Reference yield:

: 100069-69-0
(3-chloropropyl)cyclohexyl(4-fluorophenyl)methoxysilane

: 116679-83-5
p-fluorohexahydro-sila-difenidol

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / methanol / 16 h / Heating

2: 1.) n-BuLi / 1.) Et₂O, hexane, -35 deg C, 2 h, 2.) Et₂O, RT, 16 h

3: 82 percent / LiAlH₄ / dibutyl ether / 16 h / Heating

4: KOH / ethanol; H₂O / 24 h / Ambient temperature

With potassium hydroxide; lithium aluminium tetrahydride; n-butyllithium; In methanol; ethanol; dibutyl ether; water;
DOI:10.1016/0022-328X(91)80194-O

Reference yield:

: 137933-39-2
cyclohexyl(4-fluorophenyl)methoxy(3-piperidinopropyl)silane

: 116679-83-5
p-fluorohexahydro-sila-difenidol

Guidance literature:: With hydrogenchloride; In isopropyl alcohol; for 16h; Yield given; Ambient temperature;
DOI:10.1016/0022-328X(91)80194-O