4-Methyl-N-[(R)-1-methyl-4-(3-methyl-benzyl)-[1,4]diazepan-6-yl]-benzenesulfonamide

Base Information

• Chemical Name: 4-Methyl-N-[(R)-1-methyl-4-(3-methyl-benzyl)-[1,4]diazepan-6-yl]-benzenesulfonamide
• CAS No.: 199853-74-2
• Molecular Formula: C₂₁H₂₉N₃O₂S
• Molecular Weight: 387.546
• Mol file: 199853-74-2.mol

Synonyms:4-Methyl-N-[(R)-1-methyl-4-(3-methyl-benzyl)-[1,4]diazepan-6-yl]-benzenesulfonamide

Chemical Property of 4-Methyl-N-[(R)-1-methyl-4-(3-methyl-benzyl)-[1,4]diazepan-6-yl]-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Methyl-N-[(R)-1-methyl-4-(3-methyl-benzyl)-[1,4]diazepan-6-yl]-benzenesulfonamide

There total 22 articles about 4-Methyl-N-[(R)-1-methyl-4-(3-methyl-benzyl)-[1,4]diazepan-6-yl]-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-Methyl-N-[(R)-4-methyl-1-(3-methyl-benzyl)-2-oxo-[1,4]diazepan-6-yl]-benzenesulfonamide (199853-73-1) → 4-Methyl-N-[(R)-1-methyl-4-(3-methyl-benzyl)-[1,4]diazepan-6-yl]-benzenesulfonamide (199853-74-2)

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; xylene; for 25h; Heating;

DOI:10.1002/jhet.5570340516

Reference yield:

2-(S)-p-toluenesulfonylamino-β-alanine (21753-19-5) → 4-Methyl-N-[(R)-1-methyl-4-(3-methyl-benzyl)-[1,4]diazepan-6-yl]-benzenesulfonamide (199853-74-2)

Guidance literature:

Multi-step reaction with 10 steps

1: 96 percent / aq. NaOH / dioxane / 3 h / Ambient temperature

2: 99 percent / NaHCO₃ / dimethylformamide / 18 h / Ambient temperature

3: 89 percent / NaBH₄, LiCl / ethanol; tetrahydrofuran / 18 h / Ambient temperature

4: CF₃COOH / 1 h / Ambient temperature

5: NaHCO₃ / methanol / 4.5 h / Heating

6: NaBH₄ / tetrahydrofuran / 4 h / Ambient temperature

7: 68 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CHCl₃ / 2.5 h / Ambient temperature

8: 73 percent / ethanol. HCl / 2 h / Ambient temperature

9: diisopropyl azodicarboxylate, PPh₃ / tetrahydrofuran / 24 h / Heating

10: 100 percent / <(CH₃OCH₂CH₂O)2AlH₂>Na / toluene; xylene / 25 h / Heating

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; di-isopropyl azodicarboxylate; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride; trifluoroacetic acid; lithium chloride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; chloroform; N,N-dimethyl-formamide; toluene; xylene;

DOI:10.1002/jhet.5570340516

Reference yield:

N2-(toluene-4-sulfonyl)-L-asparagine (36212-66-5) → 4-Methyl-N-[(R)-1-methyl-4-(3-methyl-benzyl)-[1,4]diazepan-6-yl]-benzenesulfonamide (199853-74-2)

Guidance literature:

Multi-step reaction with 11 steps

1: 78 percent / Br₂, aq. NaOH / 0.25 h / 80 °C

2: 96 percent / aq. NaOH / dioxane / 3 h / Ambient temperature

3: 99 percent / NaHCO₃ / dimethylformamide / 18 h / Ambient temperature

4: 89 percent / NaBH₄, LiCl / ethanol; tetrahydrofuran / 18 h / Ambient temperature

5: CF₃COOH / 1 h / Ambient temperature

6: NaHCO₃ / methanol / 4.5 h / Heating

7: NaBH₄ / tetrahydrofuran / 4 h / Ambient temperature

8: 68 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CHCl₃ / 2.5 h / Ambient temperature

9: 73 percent / ethanol. HCl / 2 h / Ambient temperature

10: diisopropyl azodicarboxylate, PPh₃ / tetrahydrofuran / 24 h / Heating

11: 100 percent / <(CH₃OCH₂CH₂O)2AlH₂>Na / toluene; xylene / 25 h / Heating

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; di-isopropyl azodicarboxylate; bromine; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride; trifluoroacetic acid; lithium chloride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; chloroform; N,N-dimethyl-formamide; toluene; xylene;

DOI:10.1002/jhet.5570340516

upstream raw materials:

4-Methyl-N-[(R)-4-methyl-1-(3-methyl-benzyl)-2-oxo-[1,4]diazepan-6-yl]-benzenesulfonamide

2-(S)-p-toluenesulfonylamino-β-alanine

N²-(toluene-4-sulfonyl)-L-asparagine

N^α-Tosyl-N^β-(tert-butpxycarbonyl)-L-α,β-diamonopropionic acid

Downstream raw materials:

(R)-6-amino-1-methyl-4-(3-methylbenzyl)hexahydro-1,4-diazepine