1-(3-bromo-5-chloro-2-hydroxyphenyl)-3-(3-methoxy-2-nitrophenyl)propane-1,3-dione

Base Information

• Chemical Name: 1-(3-bromo-5-chloro-2-hydroxyphenyl)-3-(3-methoxy-2-nitrophenyl)propane-1,3-dione
• CAS No.: 1621457-80-4
• Molecular Formula: C₁₆H₁₁BrClNO₆
• Molecular Weight: 428.623
• Mol file: 1621457-80-4.mol

Synonyms:1-(3-bromo-5-chloro-2-hydroxyphenyl)-3-(3-methoxy-2-nitrophenyl)propane-1,3-dione

Chemical Property of 1-(3-bromo-5-chloro-2-hydroxyphenyl)-3-(3-methoxy-2-nitrophenyl)propane-1,3-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-bromo-5-chloro-2-hydroxyphenyl)-3-(3-methoxy-2-nitrophenyl)propane-1,3-dione

There total 3 articles about 1-(3-bromo-5-chloro-2-hydroxyphenyl)-3-(3-methoxy-2-nitrophenyl)propane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-acetyl-6-bromo-4-chlorophenyl 3-methoxy-2-nitrobenzoate (1621457-77-9) → 1-(3-bromo-5-chloro-2-hydroxyphenyl)-3-(3-methoxy-2-nitrophenyl)propane-1,3-dione (1621457-80-4)

Guidance literature:

With potassium hydroxide; In pyridine; at 100 ℃; for 0.5h; Microwave irradiation;

DOI:10.1016/j.ejmech.2014.07.018

Reference yield:

2-nitro-3-methoxybenzoyl chloride (15865-57-3) → 1-(3-bromo-5-chloro-2-hydroxyphenyl)-3-(3-methoxy-2-nitrophenyl)propane-1,3-dione (1621457-80-4)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / toluene / 2.5 h / 20 °C / Cooling with ice

2: potassium hydroxide / pyridine / 0.5 h / 100 °C / Microwave irradiation

With pyridine; potassium hydroxide; In pyridine; toluene;

DOI:10.1016/j.ejmech.2014.07.018

Reference yield:

3-methoxy-2-nitrobenzoic acid (4920-80-3) → 1-(3-bromo-5-chloro-2-hydroxyphenyl)-3-(3-methoxy-2-nitrophenyl)propane-1,3-dione (1621457-80-4)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / toluene / 20 h / Reflux

2: pyridine / toluene / 2.5 h / 20 °C / Cooling with ice

3: potassium hydroxide / pyridine / 0.5 h / 100 °C / Microwave irradiation

With pyridine; thionyl chloride; potassium hydroxide; In pyridine; toluene;

DOI:10.1016/j.ejmech.2014.07.018

upstream raw materials:

2-nitro-3-methoxybenzoyl chloride

3-methoxy-2-nitrobenzoic acid

2-acetyl-6-bromo-4-chlorophenyl 3-methoxy-2-nitrobenzoate

Downstream raw materials:

2-(2-amino-3-methoxyphenyl)-6-chloro-8-((3-(dimethylamino)propyl)amino)-4H-chromen-4-one

2-(2-amino-3-methoxyphenyl)-8-((3-aminopropyl)amino)-6-chloro-4H-chromen-4-one

2-(2-amino-3-methoxyphenyl)-8-(benzylamino)-6-chloro-4H-chromen-4-one

2-(2-amino-3-methoxyphenyl)-6-chloro-8-((tetrahydro-2H-pyran-4-yl)amino)-4H-chromen-4-one