1-((2-trimethylsilylethoxy)methyl)-6-(2,6-dichlorophenylthio)thymine

Base Information

Chemical Name:1-((2-trimethylsilylethoxy)methyl)-6-(2,6-dichlorophenylthio)thymine
CAS No.:1393847-31-8
Molecular Formula:C₁₇H₂₂Cl₂N₂O₃SSi
Molecular Weight:433.431
Hs Code.:

Synonyms:1-((2-trimethylsilylethoxy)methyl)-6-(2,6-dichlorophenylthio)thymine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-((2-trimethylsilylethoxy)methyl)-6-(2,6-dichlorophenylthio)thymine

Chemical Property:

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Technology Process of 1-((2-trimethylsilylethoxy)methyl)-6-(2,6-dichlorophenylthio)thymine

There total 4 articles about 1-((2-trimethylsilylethoxy)methyl)-6-(2,6-dichlorophenylthio)thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1393847-15-8
6-chloro-1-((2-trimethylsilylethoxy)methyl)thymine

: 4184-39-8
1,3-dichloro-2-[(2,6-dichlorophenyl)disulfanyl]benzene

: 1393847-31-8
1-((2-trimethylsilylethoxy)methyl)-6-(2,6-dichlorophenylthio)thymine

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.04.038

Reference yield:

: 2417-22-3,697787-37-4
5-methylbarbituric acid

: 1393847-31-8
1-((2-trimethylsilylethoxy)methyl)-6-(2,6-dichlorophenylthio)thymine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-benzyl-N,N,N-triethylammonium chloride; trichlorophosphate / 7 h / 50 °C / Inert atmosphere

2.1: N,O-bis-(trimethylsilyl)-acetamide / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.2: 2 h / 0 °C / Inert atmosphere

3.1: sodium tetrahydroborate / methanol / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; N,O-bis-(trimethylsilyl)-acetamide; N-benzyl-N,N,N-triethylammonium chloride; trichlorophosphate; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2012.04.038

Reference yield:

: 24966-39-0
2,6-dichlorothiophenol

: 1393847-31-8
1-((2-trimethylsilylethoxy)methyl)-6-(2,6-dichlorophenylthio)thymine

Guidance literature:: Multi-step reaction with 2 steps

1: dimethyl sulfoxide / 4 h / 80 - 90 °C

2: sodium tetrahydroborate / methanol / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; dimethyl sulfoxide; In methanol;
DOI:10.1016/j.ejmech.2012.04.038