Technology Process of 4-(bromomethyl)-2-(3,5-diphenylpyridazin-4-yl)oxazole
There total 13 articles about 4-(bromomethyl)-2-(3,5-diphenylpyridazin-4-yl)oxazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
phosphorus tribromide;
In
dichloromethane;
at 0 - 20 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -30 °C
2: phosphorus tribromide / dichloromethane / 12 h / 0 - 20 °C
With
lithium aluminium tetrahydride; phosphorus tribromide;
In
tetrahydrofuran; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; 1,4-dioxane / 12 h / 100 °C / Inert atmosphere
2.1: potassium hydroxide; water / methanol / 12 h / 100 °C
3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 20 °C
3.2: 20 °C
4.1: diethylamino-sulfur trifluoride / dichloromethane / 2 h / -76 °C
4.2: -78 - 20 °C
5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; Bromotrichloromethane / dichloromethane / 3 h / 0 °C
6.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -30 °C
7.1: phosphorus tribromide / dichloromethane / 12 h / 0 - 20 °C
With
lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium(0); Bromotrichloromethane; diethylamino-sulfur trifluoride; water; phosphorus tribromide; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
