Einecs 280-202-5

Base Information

Chemical Name:Einecs 280-202-5
CAS No.:83161-01-7
Molecular Formula:C60H55ClN5O15P
Molecular Weight:1152.55
Hs Code.:
European Community (EC) Number:280-202-5
DSSTox Substance ID:DTXSID101105228
Nikkaji Number:J278.763F

Synonyms:EINECS 280-202-5;83161-01-7;N-Benzoyl-P-(p-chlorophenyl)-2'-deoxycytidylyl-(3'.5')-5'-O-(p,p'-dimethoxytrityl)thymidine 3'-benzoate;DTXSID101105228;Thymidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-P-(4-chlorophenyl)-2'-deoxycytidylyl-(3'-->5')-, 3'-benzoate

Suppliers and Price of Einecs 280-202-5

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Einecs 280-202-5

Chemical Property:

XLogP3:8.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:15
Rotatable Bond Count:22
Exact Mass:1151.3120808
Heavy Atom Count:82
Complexity:2330

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(OC3CC(OC3COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)N7C=CC(=NC7=O)NC(=O)C8=CC=CC=C8)OC9=CC=C(C=C9)Cl)OC(=O)C1=CC=CC=C1
Isomeric SMILES:CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)COP(=O)(O[C@H]3C[C@@H](O[C@@H]3COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)N7C=CC(=NC7=O)NC(=O)C8=CC=CC=C8)OC9=CC=C(C=C9)Cl)OC(=O)C1=CC=CC=C1

Technology Process of Einecs 280-202-5

There total 3 articles about Einecs 280-202-5 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67219-55-0
4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine

: 83161-01-7
C₆₀H₅₅ClN₅O₁₅P

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine, triazole / pyridine; dioxane / 1.) 0 deg C, 1 h; 2.) room temp., 1 h

2: mesitylenesulfonyl 4-nitroimidazolide / N-methylimidazole / pyridine / 3 h / Ambient temperature

With 1,2,3-triazole; mesitylenesulfonyl 4-nitro-imidazolide; triethylamine; 1-methyl-1H-imidazole; In 1,4-dioxane; pyridine;
DOI:10.1248/cpb.30.3951

Reference yield:

: 772-79-2
4-chlorophenylphosphorodichloridate

: 83161-01-7
C₆₀H₅₅ClN₅O₁₅P

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine, triazole / pyridine; dioxane / 1.) 0 deg C, 1 h; 2.) room temp., 1 h

2: mesitylenesulfonyl 4-nitroimidazolide / N-methylimidazole / pyridine / 3 h / Ambient temperature

With 1,2,3-triazole; mesitylenesulfonyl 4-nitro-imidazolide; triethylamine; 1-methyl-1H-imidazole; In 1,4-dioxane; pyridine;
DOI:10.1248/cpb.30.3951

Reference yield:

: 17331-53-2
3'-O-benzoylthymidine

: 66274-77-9
4-chlorophenyl 5'-O-(4,4'-dimethoxytrityl)-N⁴-benzoyl-2'-deoxycytidin-3'-yl phosphate

: 83161-01-7
C₆₀H₅₅ClN₅O₁₅P

Guidance literature:: With mesitylenesulfonyl 4-nitro-imidazolide; 1-methyl-1H-imidazole; In pyridine; for 3h; Ambient temperature;
DOI:10.1248/cpb.30.3951