(2R,3S)-diphenylmethyl-3-<(benzyloxycarbonyl)oxy>-2-fluorotetradecanoate

Base Information

Chemical Name:(2R,3S)-diphenylmethyl-3-<(benzyloxycarbonyl)oxy>-2-fluorotetradecanoate
CAS No.:137344-81-1
Molecular Formula:C₃₅H₄₃FO₅
Molecular Weight:562.722
Hs Code.:

Synonyms:(2R,3S)-diphenylmethyl-3-<(benzyloxycarbonyl)oxy>-2-fluorotetradecanoate

Suppliers and Price of (2R,3S)-diphenylmethyl-3-<(benzyloxycarbonyl)oxy>-2-fluorotetradecanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (2R,3S)-diphenylmethyl-3-<(benzyloxycarbonyl)oxy>-2-fluorotetradecanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of (2R,3S)-diphenylmethyl-3-<(benzyloxycarbonyl)oxy>-2-fluorotetradecanoate

There total 14 articles about (2R,3S)-diphenylmethyl-3-<(benzyloxycarbonyl)oxy>-2-fluorotetradecanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 137344-80-0
(2R,3S)-diphenylmethyl-2-fluoro-3-hydroxytetradecanoate

: 501-53-1,94274-21-2
benzyl chloroformate

: 137344-81-1
(2R,3S)-diphenylmethyl-3-<(benzyloxycarbonyl)oxy>-2-fluorotetradecanoate

Guidance literature:: With dmap; In dichloromethane; 1) 30 min, 0 deg C, 2) 30 min, rt;
DOI:10.1016/S0040-4020(01)96156-3

Reference yield:

: 64526-50-7,137344-73-1
methyl 4-O-benzyl-2,3-dideoxy-α,β-D-erythro-hexopyranoside

: 137344-81-1
(2R,3S)-diphenylmethyl-3-<(benzyloxycarbonyl)oxy>-2-fluorotetradecanoate

Guidance literature:: Multi-step reaction with 9 steps

1: 63 percent / Jones reagent / acetone / 1 h / 0 °C

2: ethyl acetate; diethyl ether / Ambient temperature

3: 0.5percent aq. H₂SO₄ / dioxane; H₂O / 3 h / 70 - 75 °C

4: 55 percent / tetrahydrofuran; hexane / 0.25 h / Ambient temperature

5: 34 percent / Et₂NSF₃ / CH₂Cl₂ / 2 h / Ambient temperature

6: 87 mg / 1 M NaOH / ethanol / 2 h / Ambient temperature

7: 71 mg / H₂ / 10percent Pd/C / acetic acid / 8 h / Ambient temperature

8: 60 mg / ethyl acetate / 1 h / Ambient temperature

9: 95 percent / DMAP / CH₂Cl₂ / 1) 30 min, 0 deg C, 2) 30 min, rt

With dmap; sodium hydroxide; jones reagent; diethylamino-sulfur trifluoride; sulfuric acid; hydrogen; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; hexane; dichloromethane; water; acetic acid; ethyl acetate; acetone;
DOI:10.1016/S0040-4020(01)96156-3

Reference yield:

: 137344-76-4,137344-77-5
methyl 4-O-benzyl-2,3-dideoxy-α,β-D-erythro-hexopyranuronate

: 137344-81-1
(2R,3S)-diphenylmethyl-3-<(benzyloxycarbonyl)oxy>-2-fluorotetradecanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 55 percent / tetrahydrofuran; hexane / 0.25 h / Ambient temperature

2: 34 percent / Et₂NSF₃ / CH₂Cl₂ / 2 h / Ambient temperature

3: 87 mg / 1 M NaOH / ethanol / 2 h / Ambient temperature

4: 71 mg / H₂ / 10percent Pd/C / acetic acid / 8 h / Ambient temperature

5: 60 mg / ethyl acetate / 1 h / Ambient temperature

6: 95 percent / DMAP / CH₂Cl₂ / 1) 30 min, 0 deg C, 2) 30 min, rt

With dmap; sodium hydroxide; diethylamino-sulfur trifluoride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; acetic acid; ethyl acetate;
DOI:10.1016/S0040-4020(01)96156-3