2-[4'-(2''-fluoroethoxy)-3'-methoxyphenyl]-6-iodoimidazo[1,2-a]pyridine

Base Information

• Chemical Name: 2-[4'-(2''-fluoroethoxy)-3'-methoxyphenyl]-6-iodoimidazo[1,2-a]pyridine
• CAS No.: 1147548-92-2
• Molecular Formula: C₁₆H₁₄FIN₂O₂
• Molecular Weight: 412.202

Synonyms:2-[4'-(2''-fluoroethoxy)-3'-methoxyphenyl]-6-iodoimidazo[1,2-a]pyridine

Chemical Property of 2-[4'-(2''-fluoroethoxy)-3'-methoxyphenyl]-6-iodoimidazo[1,2-a]pyridine

Chemical Property:

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Technology Process of 2-[4'-(2''-fluoroethoxy)-3'-methoxyphenyl]-6-iodoimidazo[1,2-a]pyridine

There total 1 articles about 2-[4'-(2''-fluoroethoxy)-3'-methoxyphenyl]-6-iodoimidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4'-hydroxy-3'-methoxyphenyl)-6-iodoimidazo[1,2-a]pyridine (1147548-93-3) + 2-fluoroethyl tosylate (383-50-6) → 2-[4'-(2''-fluoroethoxy)-3'-methoxyphenyl]-6-iodoimidazo[1,2-a]pyridine (1147548-92-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

2-[4'-(2''-fluoroethoxy)-3'-methoxyphenyl]-6-iodoimidazo[1,2-a]pyridine (1147548-92-2) + bis(tri-n-butyltin) (813-19-4) → 6-tributylstannyl-2-[4'-(2''-fluoroethoxy)-3'-methoxyphenyl]imidazo[1,2-a]pyridine (1147548-94-4)

Guidance literature:

With triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 90 ℃; for 18h;

upstream raw materials:

2-(4'-hydroxy-3'-methoxyphenyl)-6-iodoimidazo[1,2-a]pyridine

2-fluoroethyl tosylate

Downstream raw materials:

6-tributylstannyl-2-[4'-(2''-fluoroethoxy)-3'-methoxyphenyl]imidazo[1,2-a]pyridine

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