α,α-bis(4-fluorophenyl)-1-<3-(2-hydroxyphenoxy)propyl>-4-piperidinemethanol (E)-2-butenedioate (1:1)

Base Information

• Chemical Name: α,α-bis(4-fluorophenyl)-1-<3-(2-hydroxyphenoxy)propyl>-4-piperidinemethanol (E)-2-butenedioate (1:1)
• CAS No.: 117023-39-9
• Molecular Formula: C₄H₄O₄*C₂₇H₂₉F₂NO₃
• Molecular Weight: 569.602
• Mol file: 117023-39-9.mol

Synonyms:α,α-bis(4-fluorophenyl)-1-<3-(2-hydroxyphenoxy)propyl>-4-piperidinemethanol (E)-2-butenedioate (1:1)

Chemical Property of α,α-bis(4-fluorophenyl)-1-<3-(2-hydroxyphenoxy)propyl>-4-piperidinemethanol (E)-2-butenedioate (1:1)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α,α-bis(4-fluorophenyl)-1-<3-(2-hydroxyphenoxy)propyl>-4-piperidinemethanol (E)-2-butenedioate (1:1)

There total 6 articles about α,α-bis(4-fluorophenyl)-1-<3-(2-hydroxyphenoxy)propyl>-4-piperidinemethanol (E)-2-butenedioate (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

(2E)-but-2-enedioic acid (110-17-8,26099-09-2) + α,α-bis(4-fluorophenyl)-1-[3-[2-(phenylmethoxy)phenoxy]propyl]-4-piperidinemethanol (117023-36-6) → α,α-bis(4-fluorophenyl)-1-<3-(2-hydroxyphenoxy)propyl>-4-piperidinemethanol (E)-2-butenedioate (1:1) (117023-39-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; 1) ethanol, 60 deg C, overnight;

DOI:10.1021/jm00121a022

Reference yield:

O-benzylcatechol (6272-38-4) → α,α-bis(4-fluorophenyl)-1-<3-(2-hydroxyphenoxy)propyl>-4-piperidinemethanol (E)-2-butenedioate (1:1) (117023-39-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / K₂CO₃ / acetone / 24 h / Heating

2: 64 percent / Na₂CO₃, KI / butan-1-ol / Heating

3: 32 percent / 1) H₂ / 1) 5percent Pd/C / 1) ethanol, 60 deg C, overnight

With hydrogen; sodium carbonate; potassium carbonate; potassium iodide; palladium on activated charcoal; In acetone; butan-1-ol;

DOI:10.1021/jm00121a022

Reference yield:

N-benzyl isonipecotic acid ethyl ester (24228-40-8) → α,α-bis(4-fluorophenyl)-1-<3-(2-hydroxyphenoxy)propyl>-4-piperidinemethanol (E)-2-butenedioate (1:1) (117023-39-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 1) Mg / 1) THF, reflux, 15 min.; 2) THF, room temperature, overnight

2: 92 percent / H₂ / 5percent Pd/C / ethanol / 48 h / 70 °C / 2585.7 Torr

3: 64 percent / Na₂CO₃, KI / butan-1-ol / Heating

4: 32 percent / 1) H₂ / 1) 5percent Pd/C / 1) ethanol, 60 deg C, overnight

With hydrogen; sodium carbonate; magnesium; potassium iodide; palladium on activated charcoal; In ethanol; butan-1-ol;

DOI:10.1021/jm00121a022

upstream raw materials:

(2E)-but-2-enedioic acid

α,α-bis(4-fluorophenyl)-1-[3-[2-(phenylmethoxy)phenoxy]propyl]-4-piperidinemethanol

O-benzylcatechol

N-benzyl isonipecotic acid ethyl ester