Technology Process of C22H23ClBrN5O6C2H4
There total 8 articles about C22H23ClBrN5O6C2H4 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-hydroxy-5-(1,4,5,6-tetrahydropyrimidin-2-ylamino)benzoic acid hydrochloride;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
DMF (N,N-dimethyl-formamide);
at 20 ℃;
for 0.5h;
ethyl (3R)-3-(N-Gly)amino-3-(3-bromo-5-chloro-2-hydroxyphenyl)propanoate hydrochloride;
With
triethylamine;
In
DMF (N,N-dimethyl-formamide);
at 20 ℃;
for 18h;
- Guidance literature:
-
3-hydroxy-5-(1,4,5,6-tetrahydropyrimidin-2-ylamino)benzoic acid;
With
benzotriazol-1-ol;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.5h;
ethyl (3R)-3-(N-Gly)amino-3-(3-bromo-5-chloro-2-hydroxyphenyl)propanoate hydrochloride;
With
triethylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 18h;
Further stages.;
DOI:10.1016/j.bmc.2007.03.034
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 99.5 percent / sodium methoxide / methanol / 1 h / 20 °C
2.1: 100 percent / ethanol / 5 h / Heating
3.1: 70 percent / dimethylformamide / 28 h / 100 °C
4.1: 1-(3-dimethylamino-propyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole / dimethylformamide / 0.5 h / 20 °C
4.2: 40 percent / triethylamine / dimethylformamide / 18 h / 20 °C
With
sodium methylate; benzotriazol-1-ol;
In
methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2007.03.034
