(Z)-3-(3,4,5-Trimethoxy-phenyl)-acrylic acid (E)-3-(1-benzenesulfonyl-1H-indol-2-yl)-allyl ester

Base Information

• Chemical Name: (Z)-3-(3,4,5-Trimethoxy-phenyl)-acrylic acid (E)-3-(1-benzenesulfonyl-1H-indol-2-yl)-allyl ester
• CAS No.: 154578-92-4
• Molecular Formula: C₂₉H₂₇NO₇S
• Molecular Weight: 533.602
• Mol file: 154578-92-4.mol

Synonyms:(Z)-3-(3,4,5-Trimethoxy-phenyl)-acrylic acid (E)-3-(1-benzenesulfonyl-1H-indol-2-yl)-allyl ester

Chemical Property of (Z)-3-(3,4,5-Trimethoxy-phenyl)-acrylic acid (E)-3-(1-benzenesulfonyl-1H-indol-2-yl)-allyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-3-(3,4,5-Trimethoxy-phenyl)-acrylic acid (E)-3-(1-benzenesulfonyl-1H-indol-2-yl)-allyl ester

There total 6 articles about (Z)-3-(3,4,5-Trimethoxy-phenyl)-acrylic acid (E)-3-(1-benzenesulfonyl-1H-indol-2-yl)-allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(Z)3,4,5-trimethoxycinnamic acid (20329-99-1) + 1-Benzenesulfonyl-2-((E)-3-chloro-propenyl)-1H-indole (154578-91-3) → (Z)-3-(3,4,5-Trimethoxy-phenyl)-acrylic acid (E)-3-(1-benzenesulfonyl-1H-indol-2-yl)-allyl ester (154578-92-4)

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)73719-1

Reference yield:

3-(3,4,5-trimethoxyphenyl)propiolic acid (4698-21-9) → (Z)-3-(3,4,5-Trimethoxy-phenyl)-acrylic acid (E)-3-(1-benzenesulfonyl-1H-indol-2-yl)-allyl ester (154578-92-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / hydrogen / Lyndar catalyst / ethyl acetate

2: 74 percent / NaHCO₃ / dimethylformamide

With hydrogen; sodium hydrogencarbonate; Lyndar catalyst; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)73719-1

Reference yield:

2,3-Dibrom-3-<3,4,5-trimethoxy-phenyl>-propionsaeure-methylester (92020-64-9) → (Z)-3-(3,4,5-Trimethoxy-phenyl)-acrylic acid (E)-3-(1-benzenesulfonyl-1H-indol-2-yl)-allyl ester (154578-92-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 28 percent / KOH / H₂O; ethanol / Heating

2: 75 percent / hydrogen / Lyndar catalyst / ethyl acetate

3: 74 percent / NaHCO₃ / dimethylformamide

With potassium hydroxide; hydrogen; sodium hydrogencarbonate; Lyndar catalyst; In ethanol; water; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)73719-1

upstream raw materials:

(Z)3,4,5-trimethoxycinnamic acid

1-Benzenesulfonyl-2-((E)-3-chloro-propenyl)-1H-indole

3-(3,4,5-trimethoxyphenyl)propiolic acid

2,3-Dibrom-3-<3,4,5-trimethoxy-phenyl>-propionsaeure-methylester