Betamethasone butyrate propionate

Base Information

• Chemical Name: Betamethasone butyrate propionate
• CAS No.: 5534-02-1
• Molecular Formula: C₂₉H₃₉FO₇
• Molecular Weight: 518.623
• European Community (EC) Number: 682-737-3
• UNII: 50FH5AG9RW
• DSSTox Substance ID: DTXSID7022671
• Nikkaji Number: J277.648K
• Wikidata: Q27260787
• NCI Thesaurus Code: C78755
• ChEMBL ID: CHEMBL1697785
• Mol file: 5534-02-1.mol

Synonyms:betamethasone butyrate propionate

Chemical Property of Betamethasone butyrate propionate

Chemical Property:

• Melting Point: approximate 152℃
• Boiling Point: 613°Cat760mmHg
• PKA: 12.88±0.70(Predicted)
• Flash Point: 324.5°C
• PSA: 106.97000
• Density: 1.23g/cm³
• LogP: 4.20760
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Dioxane (Slightly, Sonicated), Methanol (Slightly)
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 9
• Exact Mass: 518.26798174
• Heavy Atom Count: 37
• Complexity: 1060

Purity/Quality:

99% ^*data from raw suppliers

Betamethasone-17-butyrate-21-propionate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC(=O)OC1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)C)C(=O)COC(=O)CC
• Isomeric SMILES: CCCC(=O)O[C@@]1([C@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)F)O)C)C)C(=O)COC(=O)CC
• Recent NIPH Clinical Trials: None
• Description: Betamethasone butyrate propionate (BBP) was introduced in Japan as a topical antiinflammatory agent. It is a synthetic corticosteroid with strong antiinflammatory activity at the site of inflammation but without topical or systemic side effects. On paper disk granuloma in rats, BBP was shown to have higher degree of dissociation between antiinflammation efficacy and systemic side effects than other agents in this class. Antipyretic/analgesic properties have also been reported.
• Uses: Betamethasone-17-butyrate-21-propionate are used in the treatment of vitiligo vulgaris with the combination therapy of topical steroid and vitamin D3 compound.

Technology Process of Betamethasone butyrate propionate

There total 1 articles about Betamethasone butyrate propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ Betamethasone Butyrate Propionate (5534-02-1,63079-15-2)

Guidance literature: