ethyl hydrogen (2-(3,4-difluorophenyl)-1-(3-methylbenzo[b]thiophen-2-yl)ethyl)phosphonate

Base Information

Chemical Name:ethyl hydrogen (2-(3,4-difluorophenyl)-1-(3-methylbenzo[b]thiophen-2-yl)ethyl)phosphonate
CAS No.:957059-52-8
Molecular Formula:C₁₉H₁₉F₂O₃PS
Molecular Weight:396.395
Hs Code.:

Synonyms:ethyl hydrogen (2-(3,4-difluorophenyl)-1-(3-methylbenzo[b]thiophen-2-yl)ethyl)phosphonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl hydrogen (2-(3,4-difluorophenyl)-1-(3-methylbenzo[b]thiophen-2-yl)ethyl)phosphonate

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Technology Process of ethyl hydrogen (2-(3,4-difluorophenyl)-1-(3-methylbenzo[b]thiophen-2-yl)ethyl)phosphonate

There total 8 articles about ethyl hydrogen (2-(3,4-difluorophenyl)-1-(3-methylbenzo[b]thiophen-2-yl)ethyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: diethyl (2-(3,4-difluorophenyl)-1-(3-isopropylbenzo[b]thiophen-2-yl)ethyl)phosphonate

: 957059-52-8
ethyl hydrogen (2-(3,4-difluorophenyl)-1-(3-methylbenzo[b]thiophen-2-yl)ethyl)phosphonate

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 100 ℃; for 18h;
DOI:10.1016/j.bmcl.2012.02.060

Reference yield:

: 957056-06-3
diethyl (2-(3,4-difluorophenyl)-1-(3-methylbenzo[b]thiophen-2-yl)ethyl)phosphonate

: 957059-52-8
ethyl hydrogen (2-(3,4-difluorophenyl)-1-(3-methylbenzo[b]thiophen-2-yl)ethyl)phosphonate

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 20 - 100 ℃; for 18h;

Reference yield:

: 1385122-59-7
C₁₂H₁₃BrS

: 957059-52-8
ethyl hydrogen (2-(3,4-difluorophenyl)-1-(3-methylbenzo[b]thiophen-2-yl)ethyl)phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene / 18 h / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -70 °C

2.2: 0.5 h / -70 - 20 °C

3.1: sodium azide / N,N-dimethyl-formamide / 18 h / 100 °C

With n-butyllithium; sodium azide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2012.02.060