C₃₁H₂₄F₃N₅O₃

Base Information

Chemical Name:C₃₁H₂₄F₃N₅O₃
CAS No.:1609979-50-1
Molecular Formula:C₃₁H₂₄F₃N₅O₃
Molecular Weight:571.558
Hs Code.:

C<sub>31</sub>H<sub>24</sub>F<sub>3</sub>N<sub>5</sub>O<sub>3</sub>

Synonyms:C₃₁H₂₄F₃N₅O₃

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₃₁H₂₄F₃N₅O₃

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Technology Process of C₃₁H₂₄F₃N₅O₃

There total 5 articles about C₃₁H₂₄F₃N₅O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1609979-49-8
C₂₈H₂₂F₃N₅O₃

: 106-96-7
propargyl bromide

: 1609979-50-1
C₃₁H₂₄F₃N₅O₃

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; toluene; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2014.04.014

Reference yield:

: 55268-74-1,135526-78-2,57452-31-0,57452-98-9
2-cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one

: 1609979-50-1
C₃₁H₂₄F₃N₅O₃

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / ethanol; water / 27 h / Inert atmosphere; Reflux

2.1: Chiralcel AD-H column / methanol / Resolution of racemate

3.1: pyridine / 0.25 h / 0 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: palladium 10% on activated carbon; hydrogen / ethyl acetate; methanol / 3 h

5.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

6.1: sodium hydride / N,N-dimethyl-formamide; toluene / 0 - 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In methanol; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2014.04.014

Reference yield:

: 55375-92-3,55375-90-1
(R)-(-)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one

: 1609979-50-1
C₃₁H₂₄F₃N₅O₃

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 0.25 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate; methanol / 3 h

3.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; toluene / 0 - 20 °C / Inert atmosphere

With pyridine; palladium 10% on activated carbon; hydrogen; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In methanol; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2014.04.014