methyl-2-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)acetate

Base Information

• Chemical Name: methyl-2-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)acetate
• CAS No.: 1447710-79-3
• Molecular Formula: C₂₇H₃₈N₂O₅
• Molecular Weight: 470.609

Synonyms:methyl-2-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)acetate

Chemical Property of methyl-2-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)acetate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl-2-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)acetate

There total 10 articles about methyl-2-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxylic acid (1447711-40-1) + glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) → methyl-2-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)acetate (1447710-79-3)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 25 ℃;

DOI:10.1016/j.ejmech.2013.09.015

Reference yield:

4-hydroxy-3-methylbenzoic acid (499-76-3) → methyl-2-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)acetate (1447710-79-3)

Guidance literature:

Multi-step reaction with 9 steps

1.1: sulfuric acid / 6 h / Reflux

2.1: potassium carbonate; potassium iodide / 6 h / Reflux

3.1: diethyl ether / 2 h / 0 - 30 °C

4.1: boron trifluoride diethyl etherate / dichloromethane / 1 h / 0 - 25 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

5.2: 2 h / 25 °C

6.1: palladium on activated charcoal; ammonium formate / methanol / 25 °C

7.1: potassium carbonate; potassium iodide / acetone / 12 h / Reflux

8.1: potassium hydroxide; water / ethanol / 5 h / 80 °C

9.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 25 °C

With sulfuric acid; palladium on activated charcoal; boron trifluoride diethyl etherate; water; ammonium formate; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium iodide; potassium hydroxide; In methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.ejmech.2013.09.015

Reference yield:

ethyl 1H-pyrrole-2-carboxylate (2199-43-1) → methyl-2-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)acetate (1447710-79-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 1 h / 0 - 25 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 2 h / 25 °C

3.1: palladium on activated charcoal; ammonium formate / methanol / 25 °C

4.1: potassium carbonate; potassium iodide / acetone / 12 h / Reflux

5.1: potassium hydroxide; water / ethanol / 5 h / 80 °C

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 25 °C

With palladium on activated charcoal; boron trifluoride diethyl etherate; water; ammonium formate; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium iodide; potassium hydroxide; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.ejmech.2013.09.015

upstream raw materials:

4-hydroxy-3-methylbenzoic acid

ethyl 1H-pyrrole-2-carboxylate

5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxylic acid

glycine ethyl ester hydrochloride

Downstream raw materials:

2-(5-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)acetic acid

5-(3-(4-(2-hydroxy-3,3-dimethylbutoxy)-3-methylphenyl)pentan-3-yl)-N-(2-hydroxyethyl)-1-methylpyrrole-2-carboxamide

2-(5-(3-(4-(3,3-dimethyl-2-oxobutoxy)-3-methylphenyl)pentan-3-yl)-1-methylpyrrole-2-carboxamido)acetic acid

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