1-(N(2)-benzyloxycarbonyllysyl-gamma-glutamyl)octahydro-1H-indole-2-carboxylic acid

Base Information

• Chemical Name: 1-(N(2)-benzyloxycarbonyllysyl-gamma-glutamyl)octahydro-1H-indole-2-carboxylic acid
• CAS No.: 116587-09-8
• Molecular Formula: C₂₈H₄₀N₄O₈
• Molecular Weight: 560.648
• Mol file: 116587-09-8.mol

Synonyms:1-(N(2)-benzyloxycarbonyllysyl-gamma-glutamyl)octahydro-1H-indole-2-carboxylic acid

Chemical Property of 1-(N(2)-benzyloxycarbonyllysyl-gamma-glutamyl)octahydro-1H-indole-2-carboxylic acid

Chemical Property:

• Vapor Pressure: 6.94E-34mmHg at 25°C
• Boiling Point: 888.7°Cat760mmHg
• PKA: 3.34±0.10(Predicted)
• Flash Point: 491.2°C
• PSA: 188.36000
• Density: 1.289g/cm³
• LogP: 3.42430

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(N(2)-benzyloxycarbonyllysyl-gamma-glutamyl)octahydro-1H-indole-2-carboxylic acid

There total 6 articles about 1-(N(2)-benzyloxycarbonyllysyl-gamma-glutamyl)octahydro-1H-indole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.6%

(2S,3aS,7aS)-1-[(R)-4-((S)-2-Benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoylamino)-4-carboxy-butyryl]-octahydro-indole-2-carboxylic acid (116586-22-2) → (2S,3aS,7aS)-1-(N2-benzyloxycarbonyl-L-lysyl-γ-D-glutamyl)octahydro-1H-indole-2-carboxylic acid (116587-09-8)

Guidance literature:

With trifluoroacetic acid; for 0.5h;

DOI:10.1248/cpb.37.2417

Reference yield:

Z-Lys(-Boc)-Osu (3338-34-9) → (2S,3aS,7aS)-1-(N2-benzyloxycarbonyl-L-lysyl-γ-D-glutamyl)octahydro-1H-indole-2-carboxylic acid (116587-09-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 8.7 g / sodium carbonate / tetrahydrofuran; H₂O

2: 37.6 percent / TFA / 0.5 h

With sodium carbonate; trifluoroacetic acid; In tetrahydrofuran; water;

DOI:10.1248/cpb.37.2417

Reference yield:

(2S,3aS,7aS)-1-(γ-D-glutamyl)octahydro-1H-indole-2-carboxylic acid (116586-21-1) → (2S,3aS,7aS)-1-(N2-benzyloxycarbonyl-L-lysyl-γ-D-glutamyl)octahydro-1H-indole-2-carboxylic acid (116587-09-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 8.7 g / sodium carbonate / tetrahydrofuran; H₂O

2: 37.6 percent / TFA / 0.5 h

With sodium carbonate; trifluoroacetic acid; In tetrahydrofuran; water;

DOI:10.1248/cpb.37.2417

upstream raw materials:

(2S,3aS,7aS)-1-[(R)-4-((S)-2-Benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoylamino)-4-carboxy-butyryl]-octahydro-indole-2-carboxylic acid

Z-Lys(-Boc)-Osu

(2S,3aS,7aS)-1-(γ-D-glutamyl)octahydro-1H-indole-2-carboxylic acid

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid