ethyl 2-acetaMido-3-oxobutanoate

Base Information

• Chemical Name: ethyl 2-acetaMido-3-oxobutanoate
• CAS No.: 5431-93-6
• Molecular Formula: C8H13NO4
• Molecular Weight: 187.196
• Hs Code.: 2924199090
• Mol file: 5431-93-6.mol

Synonyms:2-acetylamino-3-oxobutyric acid ethyl ester;2-Acetamido-3-oxobuttersaeure-ethylester;ethyl 2-(acetylamino)-3-oxobutanoate;ethyl 2-(acetylamino)acetoacetate;Ethyl acetylaminoacetoacetic ester;

Chemical Property of ethyl 2-acetaMido-3-oxobutanoate

Chemical Property:

• Vapor Pressure: 0.000275mmHg at 25°C
• Melting Point: 141 °C
• Boiling Point: 322.7°C at 760 mmHg
• PKA: 10.78±0.59(Predicted)
• Flash Point: 149°C
• PSA: 72.47000
• Density: 1.117g/cm³
• LogP: 0.03410

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 2-acetamido-3-oxobutanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2-acetaMido-3-oxobutanoate

There total 24 articles about ethyl 2-acetaMido-3-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

acetic anhydride (108-24-7) + ethyl 2-hydroxyimino-3-oxobutanoate (5408-04-8) → ethyl 2-(acetylamino)-3-oxobutanoate (5431-93-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; at 20 ℃; for 3h; under 3102.97 Torr;

Reference yield: 92.3%

2-hydroxyiminoacetoacetic acid ethyl ester → ethyl 2-(acetylamino)-3-oxobutanoate (5431-93-6)

Guidance literature:

With hydrogen; acetic anhydride; palladium;

Reference yield: 91.0%

ethyl α,α-diazidoacetoacetate (110694-84-3) + acetic anhydride (108-24-7) → ethyl 2-(acetylamino)-3-oxobutanoate (5431-93-6)

Guidance literature:

With 15 mol% Pd/C; hydrogen; at 23 ℃; under 5171.62 Torr; Autoclave;

DOI:10.1016/j.tetlet.2017.09.066

upstream raw materials:

2-acetamido-3-ethoxy-3-oxopropanoic acid

acetic anhydride

3-oxo-2-(phenylhydrazono)butyric acid ethyl ester

ethyl 2-hydroxyimino-3-oxobutanoate

Downstream raw materials:

ethyl acetamidoacetate

ethyl acetate

2,5-Dimethyl-4-oxazolcarbonsaeure-ethylester

DL-threonine

Refernces

• 1、 Guan, Yu-Qing,Gao, Min,Deng, Xu,Lv, Hui,Zhang, Xumu. "Rhodium-catalyzed asymmetric hydrogenation of tetrasubstituted β-acetoxy-α-enamido esters and efficient synthesis of droxidopa". . p. 8136 - 8139. Retrieved 2017/07/24.
• 2、 -. "HETEROCYCLICALLY SUBSTITUTED TRIFLUOROMETHYLPYRIMIDINONES AND THEIR USE". Paragraph 0212. . Retrieved 2017/02/24.