(2R,4R,5R)-2,4,5-triphenylpiperidine

Base Information

Chemical Name:(2R,4R,5R)-2,4,5-triphenylpiperidine
CAS No.:1380402-78-7
Molecular Formula:C₂₃H₂₃N
Molecular Weight:313.442
Hs Code.:

Synonyms:(2R,4R,5R)-2,4,5-triphenylpiperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4R,5R)-2,4,5-triphenylpiperidine

Chemical Property:

Purity/Quality:

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Technology Process of (2R,4R,5R)-2,4,5-triphenylpiperidine

There total 6 articles about (2R,4R,5R)-2,4,5-triphenylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1380402-77-6
(3R,4R)-3,4,6-triphenyl-2,3,4,5-tetrahydropyridine

: 1380402-78-7
(2R,4R,5R)-2,4,5-triphenylpiperidine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 16h; under 760.051 Torr;
DOI:10.1002/anie.201109061

Reference yield:

: 103-82-2
phenylacetic acid

: 1380402-78-7
(2R,4R,5R)-2,4,5-triphenylpiperidine

Guidance literature:: Multi-step reaction with 4 steps

1: (R)-(+)-2-phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2: naphthalene; sodium / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere

3: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / ethyl acetate / 16 h / 20 °C / 760.05 Torr

With (R)-(+)-2-phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole; lithium aluminium tetrahydride; naphthalene; palladium 10% on activated carbon; hydrogen; sodium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate;
DOI:10.1002/anie.201109061

Reference yield:

: 614-47-1
1,3-diphenyl-propen-3-one

: 1380402-78-7
(2R,4R,5R)-2,4,5-triphenylpiperidine

Guidance literature:: Multi-step reaction with 5 steps

1: titanium tetrachloride; triethylamine / dichloromethane / 16 h / 0 °C / Reflux; Inert atmosphere

2: (R)-(+)-2-phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

3: naphthalene; sodium / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere

4: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 °C / Inert atmosphere

5: palladium 10% on activated carbon; hydrogen / ethyl acetate / 16 h / 20 °C / 760.05 Torr

With (R)-(+)-2-phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole; lithium aluminium tetrahydride; naphthalene; palladium 10% on activated carbon; hydrogen; sodium; titanium tetrachloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1002/anie.201109061