2-allyl-9-(2-chlorophenyl)-7-fluoro-6-methoxy-1-methyl-2,4-dihydro-2,3,4,10-tetraazabenzo[f]azulene

Base Information

Chemical Name:2-allyl-9-(2-chlorophenyl)-7-fluoro-6-methoxy-1-methyl-2,4-dihydro-2,3,4,10-tetraazabenzo[f]azulene
CAS No.:1420683-99-3
Molecular Formula:C₂₁H₁₈ClFN₄O
Molecular Weight:396.852
Hs Code.:

Synonyms:2-allyl-9-(2-chlorophenyl)-7-fluoro-6-methoxy-1-methyl-2,4-dihydro-2,3,4,10-tetraazabenzo[f]azulene

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Chemical Property of 2-allyl-9-(2-chlorophenyl)-7-fluoro-6-methoxy-1-methyl-2,4-dihydro-2,3,4,10-tetraazabenzo[f]azulene

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Technology Process of 2-allyl-9-(2-chlorophenyl)-7-fluoro-6-methoxy-1-methyl-2,4-dihydro-2,3,4,10-tetraazabenzo[f]azulene

There total 9 articles about 2-allyl-9-(2-chlorophenyl)-7-fluoro-6-methoxy-1-methyl-2,4-dihydro-2,3,4,10-tetraazabenzo[f]azulene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.6%

: 882532-15-2
(1-allyl-5-chloro-3-methyl-1H-pyrazol-4-yl)amine

: 882531-35-3
(2-amino-5-fluoro-4-methoxyphenyl)(2-chlorophenyl)methanone

: 1420683-99-3
2-allyl-9-(2-chlorophenyl)-7-fluoro-6-methoxy-1-methyl-2,4-dihydro-2,3,4,10-tetraazabenzo[f]azulene

Guidance literature:: With toluene-4-sulfonic acid; In isopropyl alcohol; at 170 ℃; for 15h; Microwave irradiation;
DOI:10.1021/ml300351e

Reference yield:

: 882532-26-5
ethyl 5-amino-3-methyl-1-(2-propenyl)-1H-pyrazole-4-carboxylate

: 1420683-99-3
2-allyl-9-(2-chlorophenyl)-7-fluoro-6-methoxy-1-methyl-2,4-dihydro-2,3,4,10-tetraazabenzo[f]azulene

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; copper dichloride; sodium nitrite / water / 3.33 h / 0 - 40 °C

2.1: sodium hydroxide / methanol; water; tetrahydrofuran / 4 h / 65 °C

2.2: pH 1 - 2

3.1: triethylamine; chloroformic acid ethyl ester / acetone / 0.5 h / -10 °C

3.2: 1 h / 20 °C

4.1: toluene / 1 h / 100 °C

4.2: 2 h / 110 °C

5.1: toluene-4-sulfonic acid / isopropyl alcohol / 15 h / 170 °C / Microwave irradiation

With hydrogenchloride; chloroformic acid ethyl ester; toluene-4-sulfonic acid; triethylamine; sodium hydroxide; copper dichloride; sodium nitrite; In tetrahydrofuran; methanol; water; isopropyl alcohol; acetone; toluene; 4.1: |Curtius Rearrangement;
DOI:10.1021/ml300351e

Reference yield:

: 882532-29-8
5-chloro-3-methyl-1-(2-propenyl)-1H-pyrazole-4-carbonyl azide

: 1420683-99-3
2-allyl-9-(2-chlorophenyl)-7-fluoro-6-methoxy-1-methyl-2,4-dihydro-2,3,4,10-tetraazabenzo[f]azulene

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene / 1 h / 100 °C

1.2: 2 h / 110 °C

2.1: toluene-4-sulfonic acid / isopropyl alcohol / 15 h / 170 °C / Microwave irradiation

With toluene-4-sulfonic acid; In isopropyl alcohol; toluene; 1.1: |Curtius Rearrangement;
DOI:10.1021/ml300351e