(-)-9-[2,3-dideoxy-3,3-difluoro-4-(O-tert-butyldiphenylsilyloxymethyl)-cyclopentanyl]adenine

Base Information

Chemical Name:(-)-9-[2,3-dideoxy-3,3-difluoro-4-(O-tert-butyldiphenylsilyloxymethyl)-cyclopentanyl]adenine
CAS No.:935683-91-3
Molecular Formula:C₂₇H₃₁F₂N₅OSi
Molecular Weight:507.658
Hs Code.:

Synonyms:(-)-9-[2,3-dideoxy-3,3-difluoro-4-(O-tert-butyldiphenylsilyloxymethyl)-cyclopentanyl]adenine

Suppliers and Price of (-)-9-[2,3-dideoxy-3,3-difluoro-4-(O-tert-butyldiphenylsilyloxymethyl)-cyclopentanyl]adenine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (-)-9-[2,3-dideoxy-3,3-difluoro-4-(O-tert-butyldiphenylsilyloxymethyl)-cyclopentanyl]adenine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (-)-9-[2,3-dideoxy-3,3-difluoro-4-(O-tert-butyldiphenylsilyloxymethyl)-cyclopentanyl]adenine

There total 6 articles about (-)-9-[2,3-dideoxy-3,3-difluoro-4-(O-tert-butyldiphenylsilyloxymethyl)-cyclopentanyl]adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1025831-63-3
C₂₇H₂₉ClF₂N₄OSi

: 935683-91-3
(-)-9-[2,3-dideoxy-3,3-difluoro-4-(O-tert-butyldiphenylsilyloxymethyl)-cyclopentanyl]adenine

Guidance literature:: With ammonia; In methanol; at 100 ℃; for 24h;
DOI:10.1021/jm061304k

Reference yield:

: 855662-67-8
(+)-(1R,2S,3S,4R)-1-O-benzyloxy-2,3-anhydro-4-hydroxymethylcyclopentane

: 935683-91-3
(-)-9-[2,3-dideoxy-3,3-difluoro-4-(O-tert-butyldiphenylsilyloxymethyl)-cyclopentanyl]adenine

Guidance literature:: Multi-step reaction with 8 steps

1: 91 percent / triethylamine; DMAP / CH₂Cl₂ / 24 h / 20 °C

2: 92 percent / Super-Hydride / tetrahydrofuran / 0.5 h / 20 °C

3: 81 percent / pyridinium dichromate; acetic acid; 4 Angstroem molecular sieves / CH₂Cl₂ / 3 h / 20 °C

4: 68 percent / diethylaminosulfur trifluoride / 36 h / 40 °C

5: 70 percent / iodotrimethylsilane / CH₂Cl₂ / 14 h / 20 °C

6: 74 percent / imidazole / CH₂Cl₂ / 1.75 h / 0 °C

7: triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran; dioxane / 24.5 h / -78 - 20 °C

8: 305 mg / NH₃ / methanol / 24 h / 100 °C

With 1H-imidazole; dmap; dipyridinium dichromate; trimethylsilyl iodide; diethylamino-sulfur trifluoride; di-isopropyl azodicarboxylate; 4 A molecular sieve; ammonia; lithium triethylborohydride; acetic acid; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; 7: Mitsunobu reaction;
DOI:10.1021/jm061304k

Reference yield:

: 935683-77-5
(+)-4-O-benzyloxy-1,1-difluoro-2-(O-triphenylmethyloxymethyl)-cyclopentane

: 935683-91-3
(-)-9-[2,3-dideoxy-3,3-difluoro-4-(O-tert-butyldiphenylsilyloxymethyl)-cyclopentanyl]adenine

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / iodotrimethylsilane / CH₂Cl₂ / 14 h / 20 °C

2: 74 percent / imidazole / CH₂Cl₂ / 1.75 h / 0 °C

3: triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran; dioxane / 24.5 h / -78 - 20 °C

4: 305 mg / NH₃ / methanol / 24 h / 100 °C

With 1H-imidazole; trimethylsilyl iodide; di-isopropyl azodicarboxylate; ammonia; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; 3: Mitsunobu reaction;
DOI:10.1021/jm061304k