8-methoxy-5-(2,2-diphenylvinylidene)-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1-benzazepine

Base Information

Chemical Name:8-methoxy-5-(2,2-diphenylvinylidene)-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1-benzazepine
CAS No.:735271-38-2
Molecular Formula:C₃₂H₂₉NO₃S
Molecular Weight:507.653
Hs Code.:

Synonyms:8-methoxy-5-(2,2-diphenylvinylidene)-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1-benzazepine

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Chemical Property of 8-methoxy-5-(2,2-diphenylvinylidene)-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1-benzazepine

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Technology Process of 8-methoxy-5-(2,2-diphenylvinylidene)-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1-benzazepine

There total 6 articles about 8-methoxy-5-(2,2-diphenylvinylidene)-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 735271-36-0
N-(6-trimethylsiloxy-6,6-diphenyl-4-hexynyl)-N-(p-toluenesulfonyl)-m-methoxyaniline

: 735271-38-2
8-methoxy-5-(2,2-diphenylvinylidene)-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1-benzazepine

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at 0 ℃; for 0.166667h;
DOI:10.1021/ol049301u

Reference yield:

: 58750-87-1
N-tosyl-m-anisidine

: 735271-38-2
8-methoxy-5-(2,2-diphenylvinylidene)-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1-benzazepine

Guidance literature:: Multi-step reaction with 4 steps

1: PPh₃; DEAD / tetrahydrofuran / 20 °C

2: BuLi / tetrahydrofuran / 0 °C

3: imidazole / dimethylformamide / 20 °C

4: 90 percent / BF₃*OEt₂ / CH₂Cl₂ / 0.17 h / 0 °C

With 1H-imidazole; n-butyllithium; boron trifluoride diethyl etherate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: Mitsunobu reaction / 4: Friedel-Crafts reaction;
DOI:10.1021/ol049301u

Reference yield:

: 536-90-3,918666-97-4
m-Anisidine

: 735271-38-2
8-methoxy-5-(2,2-diphenylvinylidene)-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1-benzazepine

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / Et₃N / tetrahydrofuran / 15 h / 20 °C

2: PPh₃; DEAD / tetrahydrofuran / 20 °C

3: BuLi / tetrahydrofuran / 0 °C

4: imidazole / dimethylformamide / 20 °C

5: 90 percent / BF₃*OEt₂ / CH₂Cl₂ / 0.17 h / 0 °C

With 1H-imidazole; n-butyllithium; boron trifluoride diethyl etherate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2: Mitsunobu reaction / 5: Friedel-Crafts reaction;
DOI:10.1021/ol049301u