(2S,4S)-4-azido-1-cyclohexylmethyl-pyrrolidine-2-carboxylic acid methyl ester

Base Information

Chemical Name:(2S,4S)-4-azido-1-cyclohexylmethyl-pyrrolidine-2-carboxylic acid methyl ester
CAS No.:1451054-80-0
Molecular Formula:C₁₃H₂₂N₄O₂
Molecular Weight:266.343
Hs Code.:

Synonyms:(2S,4S)-4-azido-1-cyclohexylmethyl-pyrrolidine-2-carboxylic acid methyl ester

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Chemical Property of (2S,4S)-4-azido-1-cyclohexylmethyl-pyrrolidine-2-carboxylic acid methyl ester

Chemical Property:

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Technology Process of (2S,4S)-4-azido-1-cyclohexylmethyl-pyrrolidine-2-carboxylic acid methyl ester

There total 4 articles about (2S,4S)-4-azido-1-cyclohexylmethyl-pyrrolidine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 84520-70-7
(2S,4S)-4-azido-pyrrolidine-2-carboxylic acid methyl ester trifluoroacetate

: 2043-61-0
cyclohexanecarbaldehyde

: 1451054-80-0
(2S,4S)-4-azido-1-cyclohexylmethyl-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; for 20h;

Reference yield:

: 74844-91-0
1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate

: 1451054-80-0
(2S,4S)-4-azido-1-cyclohexylmethyl-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 16 h / 0 °C / Reflux

2: sodium azide / N,N-dimethyl-formamide / 16 h / 60 °C

3: dichloromethane / 16 h / 20 °C

4: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 20 h / 20 °C

With pyridine; sodium azide; sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 88043-21-4
(2S,4R)-4-(toluene-4-sulfonyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

: 1451054-80-0
(2S,4S)-4-azido-1-cyclohexylmethyl-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide / N,N-dimethyl-formamide / 16 h / 60 °C

2: dichloromethane / 16 h / 20 °C

3: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 20 h / 20 °C

With sodium azide; sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; N,N-dimethyl-formamide;