3-<(2ξ)-2-<(1ξ,3S,5R)-3,5-dimethyl-2-methylenecyclopentyl>-1-oxo>propyl-1-(phenylsulfonyl)-1H-pyrrole

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Chemical Name:3-<(2ξ)-2-<(1ξ,3S,5R)-3,5-dimethyl-2-methylenecyclopentyl>-1-oxo>propyl-1-(phenylsulfonyl)-1H-pyrrole
CAS No.:143949-40-0
Molecular Formula:C₂₁H₂₅NO₃S
Molecular Weight:371.5
Hs Code.:

Synonyms:3-<(2ξ)-2-<(1ξ,3S,5R)-3,5-dimethyl-2-methylenecyclopentyl>-1-oxo>propyl-1-(phenylsulfonyl)-1H-pyrrole

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Chemical Property of 3-<(2ξ)-2-<(1ξ,3S,5R)-3,5-dimethyl-2-methylenecyclopentyl>-1-oxo>propyl-1-(phenylsulfonyl)-1H-pyrrole

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Technology Process of 3-<(2ξ)-2-<(1ξ,3S,5R)-3,5-dimethyl-2-methylenecyclopentyl>-1-oxo>propyl-1-(phenylsulfonyl)-1H-pyrrole

There total 4 articles about 3-<(2ξ)-2-<(1ξ,3S,5R)-3,5-dimethyl-2-methylenecyclopentyl>-1-oxo>propyl-1-(phenylsulfonyl)-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 143949-39-7
ethyl (αξ)-α-<(1ξ,3S,5R)-3,5-dimethyl-2-methylenecyclopentyl>-α-methyl-β-oxo-1-(phenylsulfonyl)-1H-pyrrole-3-propanoate

: 143949-40-0
3-<(2ξ)-2-<(1ξ,3S,5R)-3,5-dimethyl-2-methylenecyclopentyl>-1-oxo>propyl-1-(phenylsulfonyl)-1H-pyrrole

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium chloride; at 130 ℃; for 24h;
DOI:10.1016/S0040-4039(00)61322-9

Reference yield:

: 88075-95-0
1-(phenylsulfonyl)-1H-pyrrole-3-carbaldehyde

: 143949-40-0
3-<(2ξ)-2-<(1ξ,3S,5R)-3,5-dimethyl-2-methylenecyclopentyl>-1-oxo>propyl-1-(phenylsulfonyl)-1H-pyrrole

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA / 1.) THF, -68 deg C to -65 deg C, 40 min, 2.) THF, -78 deg C, 40 min

2: 81 percent / MnO₂ / CH₂Cl₂ / 2 h / Heating

3: 70 percent / LiCl, H₂O / hexamethylphosphoric acid triamide / 24 h / 130 - 133 °C

With manganese(IV) oxide; water; lithium chloride; lithium diisopropyl amide; In N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1248/cpb.42.854

Reference yield:

: 143949-37-5
ethyl (αξ,1ξ,3S,5R)-2-methylene-α,3,5-trimethylcyclopentaneacetate

: 143949-40-0
3-<(2ξ)-2-<(1ξ,3S,5R)-3,5-dimethyl-2-methylenecyclopentyl>-1-oxo>propyl-1-(phenylsulfonyl)-1H-pyrrole

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA / 1.) THF, -68 deg C to -65 deg C, 40 min, 2.) THF, -78 deg C, 40 min

2: 81 percent / MnO₂ / CH₂Cl₂ / 2 h / Heating

3: 70 percent / LiCl, H₂O / hexamethylphosphoric acid triamide / 24 h / 130 - 133 °C

With manganese(IV) oxide; water; lithium chloride; lithium diisopropyl amide; In N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1248/cpb.42.854