7-[(1R,4S,5R,6R)-6-((E)-(S)-3-Hydroxy-oct-1-enyl)-3-phenyl-2-oxa-3-aza-bicyclo[2.2.1]hept-5-yl]-heptanoic acid methyl ester

Base Information

• Chemical Name: 7-[(1R,4S,5R,6R)-6-((E)-(S)-3-Hydroxy-oct-1-enyl)-3-phenyl-2-oxa-3-aza-bicyclo[2.2.1]hept-5-yl]-heptanoic acid methyl ester
• CAS No.: 121003-79-0
• Molecular Formula: C₂₇H₄₁NO₄
• Molecular Weight: 443.627

Synonyms:7-[(1R,4S,5R,6R)-6-((E)-(S)-3-Hydroxy-oct-1-enyl)-3-phenyl-2-oxa-3-aza-bicyclo[2.2.1]hept-5-yl]-heptanoic acid methyl ester

Chemical Property of 7-[(1R,4S,5R,6R)-6-((E)-(S)-3-Hydroxy-oct-1-enyl)-3-phenyl-2-oxa-3-aza-bicyclo[2.2.1]hept-5-yl]-heptanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-[(1R,4S,5R,6R)-6-((E)-(S)-3-Hydroxy-oct-1-enyl)-3-phenyl-2-oxa-3-aza-bicyclo[2.2.1]hept-5-yl]-heptanoic acid methyl ester

There total 27 articles about 7-[(1R,4S,5R,6R)-6-((E)-(S)-3-Hydroxy-oct-1-enyl)-3-phenyl-2-oxa-3-aza-bicyclo[2.2.1]hept-5-yl]-heptanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-[(1R,4S,5R,6R)-6-((E)-3-Oxo-oct-1-enyl)-3-phenyl-2-oxa-3-aza-bicyclo[2.2.1]hept-5-yl]-heptanoic acid methyl ester (125180-09-8) → 7-[(1R,4S,5R,6R)-6-((E)-(R)-3-Hydroxy-oct-1-enyl)-3-phenyl-2-oxa-3-aza-bicyclo[2.2.1]hept-5-yl]-heptanoic acid methyl ester (121003-79-0,125276-35-9,125276-36-0,125276-37-1) + 7-[(1R,4S,5R,6R)-6-((E)-(S)-3-Hydroxy-oct-1-enyl)-3-phenyl-2-oxa-3-aza-bicyclo[2.2.1]hept-5-yl]-heptanoic acid methyl ester (121003-79-0) + 7-[(1S,4R,5S,6S)-6-((E)-(R)-3-Hydroxy-oct-1-enyl)-3-phenyl-2-oxa-3-aza-bicyclo[2.2.1]hept-5-yl]-heptanoic acid methyl ester (121003-79-0,125276-35-9,125276-36-0,125276-37-1) + 7-[(1S,4R,5S,6S)-6-((E)-(S)-3-Hydroxy-oct-1-enyl)-3-phenyl-2-oxa-3-aza-bicyclo[2.2.1]hept-5-yl]-heptanoic acid methyl ester (125276-35-9)

Guidance literature:

With (-)-(S)-BINAL-H; In tetrahydrofuran; at -100 - -78 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/ja00034a062

Reference yield:

7-[(1R,4S,5R,6R)-6-((E)-3-Oxo-oct-1-enyl)-3-phenyl-2-oxa-3-aza-bicyclo[2.2.1]hept-5-yl]-heptanoic acid methyl ester (125180-09-8) → 7-[(1R,4S,5R,6R)-6-((E)-(R)-3-Hydroxy-oct-1-enyl)-3-phenyl-2-oxa-3-aza-bicyclo[2.2.1]hept-5-yl]-heptanoic acid methyl ester (121003-79-0,125276-35-9,125276-36-0,125276-37-1) + 7-[(1R,4S,5R,6R)-6-((E)-(S)-3-Hydroxy-oct-1-enyl)-3-phenyl-2-oxa-3-aza-bicyclo[2.2.1]hept-5-yl]-heptanoic acid methyl ester (121003-79-0) + 7-[(1S,4R,5S,6S)-6-((E)-(R)-3-Hydroxy-oct-1-enyl)-3-phenyl-2-oxa-3-aza-bicyclo[2.2.1]hept-5-yl]-heptanoic acid methyl ester (121003-79-0,125276-35-9,125276-36-0,125276-37-1) + 7-[(1S,4R,5S,6S)-6-((E)-(S)-3-Hydroxy-oct-1-enyl)-3-phenyl-2-oxa-3-aza-bicyclo[2.2.1]hept-5-yl]-heptanoic acid methyl ester (125276-35-9)

Guidance literature:

With (-)-(S)-BINAL-H; In tetrahydrofuran; at -100 - -78 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/ja00034a062

Reference yield:

7-[(1R,4S,5R,6R)-6-((E)-3-Oxo-oct-1-enyl)-3-phenyl-2-oxa-3-aza-bicyclo[2.2.1]hept-5-yl]-heptanoic acid methyl ester (125180-09-8) → 7-[(1R,4S,5R,6R)-6-((E)-(R)-3-Hydroxy-oct-1-enyl)-3-phenyl-2-oxa-3-aza-bicyclo[2.2.1]hept-5-yl]-heptanoic acid methyl ester (121003-79-0,125276-35-9,125276-36-0,125276-37-1) + 7-[(1R,4S,5R,6R)-6-((E)-(S)-3-Hydroxy-oct-1-enyl)-3-phenyl-2-oxa-3-aza-bicyclo[2.2.1]hept-5-yl]-heptanoic acid methyl ester (121003-79-0) + 7-[(1S,4R,5S,6S)-6-((E)-(R)-3-Hydroxy-oct-1-enyl)-3-phenyl-2-oxa-3-aza-bicyclo[2.2.1]hept-5-yl]-heptanoic acid methyl ester (121003-79-0,125276-35-9,125276-36-0,125276-37-1) + 7-[(1S,4R,5S,6S)-6-((E)-(S)-3-Hydroxy-oct-1-enyl)-3-phenyl-2-oxa-3-aza-bicyclo[2.2.1]hept-5-yl]-heptanoic acid methyl ester (125276-35-9)

Guidance literature:

With (-)-(S)-BINAL-H; In tetrahydrofuran; at -100 - -78 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/ja00034a062

upstream raw materials:

7-[(1R,4S,5R,6R)-6-((E)-3-Oxo-oct-1-enyl)-3-phenyl-2-oxa-3-aza-bicyclo[2.2.1]hept-5-yl]-heptanoic acid methyl ester

(8R,9S)-9-Acetoxymethyl-8-formyl-undec-10-enoic acid methyl ester

(8S,9R)-9-Acetoxymethyl-8-dimethylcarbamoyl-undec-10-enoic acid methyl ester

7-((1S,4R,5S,6R)-6-Hydroxymethyl-3-phenyl-2-oxa-3-aza-bicyclo[2.2.1]hept-5-yl)-heptanoic acid methyl ester

Downstream raw materials:

prostaglandin E₁ methyl ester

9α-anilino-PGF₁

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