4-amino-5-cyano-7-<3,5-O-<1,1,3,3-tetrakis(methylethyl)disiloxan-1,3-diyl>-β-D-ribofuranosyl>pyrrolo<2,3-d>pyrimidine

Base Information

Chemical Name:4-amino-5-cyano-7-<3,5-O-<1,1,3,3-tetrakis(methylethyl)disiloxan-1,3-diyl>-β-D-ribofuranosyl>pyrrolo<2,3-d>pyrimidine
CAS No.:85335-79-1
Molecular Formula:C₂₄H₃₉N₅O₅Si₂
Molecular Weight:533.775
Hs Code.:

Synonyms:4-amino-5-cyano-7-<3,5-O-<1,1,3,3-tetrakis(methylethyl)disiloxan-1,3-diyl>-β-D-ribofuranosyl>pyrrolo<2,3-d>pyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-amino-5-cyano-7-<3,5-O-<1,1,3,3-tetrakis(methylethyl)disiloxan-1,3-diyl>-β-D-ribofuranosyl>pyrrolo<2,3-d>pyrimidine

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 4-amino-5-cyano-7-<3,5-O-<1,1,3,3-tetrakis(methylethyl)disiloxan-1,3-diyl>-β-D-ribofuranosyl>pyrrolo<2,3-d>pyrimidine

There total 1 articles about 4-amino-5-cyano-7-<3,5-O-<1,1,3,3-tetrakis(methylethyl)disiloxan-1,3-diyl>-β-D-ribofuranosyl>pyrrolo<2,3-d>pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18043-71-5
1,1,3,3-tetraisopropyldisiloxane

: 85335-79-1
4-amino-5-cyano-7-<3,5-O-<1,1,3,3-tetrakis(methylethyl)disiloxan-1,3-diyl>-β-D-ribofuranosyl>pyrrolo<2,3-d>pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / Cl₂ / CCl₄ / 0.5 h

2: 89 percent / pyridine / 3 h / Ambient temperature

With pyridine; chlorine; In tetrachloromethane;
DOI:10.1021/ja00350a052

Reference yield:

: 85335-79-1
4-amino-5-cyano-7-<3,5-O-<1,1,3,3-tetrakis(methylethyl)disiloxan-1,3-diyl>-β-D-ribofuranosyl>pyrrolo<2,3-d>pyrimidine

: 1005-56-7
phenylcarbonochloridothioate

: 85335-80-4
Thiocarbonic acid O-[(2R,3R,3aR,9aR)-2-(4-amino-5-cyano-pyrrolo[2,3-d]pyrimidin-7-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl] ester O-phenyl ester

Guidance literature:: With dmap; In acetonitrile; for 16h; Ambient temperature;
DOI:10.1021/ja00350a052

Reference yield:

: 85335-79-1
4-amino-5-cyano-7-<3,5-O-<1,1,3,3-tetrakis(methylethyl)disiloxan-1,3-diyl>-β-D-ribofuranosyl>pyrrolo<2,3-d>pyrimidine

: 127880-88-0
4-amino-7-(2-deoxy-2-amino-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / 4-(dimethylamino)pyridine (4-DMAP) / 1,2-dichloro-ethane / 0 °C

2: 78 percent / lithium azide / hexamethylphosphoric acid triamide / 4 h / Ambient temperature

3: 60 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 2 h / Ambient temperature

4: 84 percent / 30percent aq. hydrogen peroxide, concd. ammonium hydroxide / 1 h

5: 120 mg / 1,3-propanedithiol, triethylamine / methanol; dimethylformamide / 3 h / Ambient temperature

With 1.3-propanedithiol; dmap; ammonium hydroxide; lithium azide; tetrabutyl ammonium fluoride; dihydrogen peroxide; triethylamine; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00174a011