3'-(4-fluorophenyl)-4-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)-ethyl]-3,4,5,6-tetrahydro-2H-[1,2']bipyrazine hydrochloride

Base Information

Chemical Name:3'-(4-fluorophenyl)-4-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)-ethyl]-3,4,5,6-tetrahydro-2H-[1,2']bipyrazine hydrochloride
CAS No.:1082060-36-3
Molecular Formula:C₂₂H₂₇FN₆*ClH
Molecular Weight:430.956
Hs Code.:

Synonyms:3'-(4-fluorophenyl)-4-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)-ethyl]-3,4,5,6-tetrahydro-2H-[1,2']bipyrazine hydrochloride

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Chemical Property of 3'-(4-fluorophenyl)-4-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)-ethyl]-3,4,5,6-tetrahydro-2H-[1,2']bipyrazine hydrochloride

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Technology Process of 3'-(4-fluorophenyl)-4-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)-ethyl]-3,4,5,6-tetrahydro-2H-[1,2']bipyrazine hydrochloride

There total 6 articles about 3'-(4-fluorophenyl)-4-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)-ethyl]-3,4,5,6-tetrahydro-2H-[1,2']bipyrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1082065-81-3
2-(1,3,5-trimethyl-1H-pyrazol-4-yl)acetaldehyde

: 889939-14-4
3'-(4-fluoro-phenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyrazine

: 1082060-36-3
3'-(4-fluorophenyl)-4-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)-ethyl]-3,4,5,6-tetrahydro-2H-[1,2']bipyrazine hydrochloride

Guidance literature:: 2-(1,3,5-trimethyl-1H-pyrazol-4-yl)acetaldehyde; 3'-(4-fluoro-phenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyrazine; In dichloromethane; at 20 ℃; for 0.166667h;

With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; for 2h;

With methanol; ammonia; ammonium chloride; more than 3 stages;

Reference yield:

: 123-54-6,81235-32-7
acetylacetone

: 1082060-36-3
3'-(4-fluorophenyl)-4-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)-ethyl]-3,4,5,6-tetrahydro-2H-[1,2']bipyrazine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

1.2: 16 h / 0 °C

2.1: acetic acid / 16 h / 20 °C

3.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 2.5 h / -78 °C

3.2: 16 h / 20 °C

4.1: dichloromethane / 0.17 h / 20 °C

4.2: 2 h / 20 °C

With sodium hydride; diisobutylaluminium hydride; acetic acid; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 889939-15-5
3-(4-fluorophenyl)-2-[4-(t-butyloxycarbonyl)piperazin-1-yl]pyrazine

: 1082060-36-3
3'-(4-fluorophenyl)-4-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)-ethyl]-3,4,5,6-tetrahydro-2H-[1,2']bipyrazine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; butan-1-ol / 2 h / 60 °C

2.1: methanol; ammonia

3.1: dichloromethane / 0.17 h / 20 °C

3.2: 2 h / 20 °C

With hydrogenchloride; methanol; ammonia; butan-1-ol; In dichloromethane;