Technology Process of C21H26O6
There total 5 articles about C21H26O6 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
diiodomethane;
In
diethyl ether; hexane;
at 0 ℃;
for 5h;
stereoselective reaction;
Inert atmosphere;
DOI:10.1021/ol302677z
- Guidance literature:
-
C21H28O6;
With
oxalyl dichloride;
In
dichloromethane; dimethyl sulfoxide;
at -78 ℃;
for 0.5h;
Inert atmosphere;
With
triethylamine;
In
dichloromethane; dimethyl sulfoxide;
at 20 ℃;
Overall yield = 115 mg;
Inert atmosphere;
DOI:10.1021/ol302677z
- Guidance literature:
-
Multi-step reaction with 3 steps
1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 4 h / -78 - 25 °C / Inert atmosphere; Molecular sieve
2: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol / 1 h / -78 °C
3: diiodomethane / hexane; diethyl ether / 5 h / 0 °C / Inert atmosphere
With
sodium tetrahydroborate; diiodomethane; trimethylsilyl trifluoromethanesulfonate; cerium(III) chloride heptahydrate;
In
methanol; diethyl ether; hexane; dichloromethane;
2: |Luche Cerium Reduction / 3: |Simmons-Smith Cyclopropanation;
DOI:10.1021/ol302677z