methyl 1-n-butyl-2-[3-(cyclohexylamino)-2-(2-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-1H-benzo[d]imidazole-5-carboxylate

Base Information

• Chemical Name: methyl 1-n-butyl-2-[3-(cyclohexylamino)-2-(2-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-1H-benzo[d]imidazole-5-carboxylate
• CAS No.: 1430101-60-2
• Molecular Formula: C₃₂H₃₄FN₅O₂
• Molecular Weight: 539.653

Synonyms:methyl 1-n-butyl-2-[3-(cyclohexylamino)-2-(2-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-1H-benzo[d]imidazole-5-carboxylate

Chemical Property of methyl 1-n-butyl-2-[3-(cyclohexylamino)-2-(2-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-1H-benzo[d]imidazole-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 1-n-butyl-2-[3-(cyclohexylamino)-2-(2-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-1H-benzo[d]imidazole-5-carboxylate

There total 6 articles about methyl 1-n-butyl-2-[3-(cyclohexylamino)-2-(2-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-1H-benzo[d]imidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

Cyclohexyl isocyanide (931-53-3) + methyl 2-(2-aminopyridin-3-yl)-1-butyl-1H-benzo[d]imidazole-5-carboxylate (1430101-84-0) + 2-Fluorobenzaldehyde (446-52-6) → methyl 1-n-butyl-2-[3-(cyclohexylamino)-2-(2-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-1H-benzo[d]imidazole-5-carboxylate (1430101-60-2)

Guidance literature:

With scandium tris(trifluoromethanesulfonate); In neat (no solvent); at 135 ℃; Microwave irradiation; Inert atmosphere; Green chemistry;

DOI:10.1021/co400010y

Reference yield:

4-fluoro-3-nitro-benzoic acid methyl ester (329-59-9) → methyl 1-n-butyl-2-[3-(cyclohexylamino)-2-(2-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-1H-benzo[d]imidazole-5-carboxylate (1430101-60-2)

Guidance literature:

Multi-step reaction with 5 steps

1: dichloromethane / 0.17 h / 80 °C / Microwave irradiation; Inert atmosphere

2: zinc; ammonium formate / methanol / 0.08 h / 90 °C / Microwave irradiation; Inert atmosphere

3: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.17 h / 160 °C / Microwave irradiation; Inert atmosphere

4: trifluoroacetic acid; magnesium sulfate / 1,2-dichloro-ethane / 0.17 h / 130 °C / Microwave irradiation; Inert atmosphere

5: scandium tris(trifluoromethanesulfonate) / neat (no solvent) / 135 °C / Microwave irradiation; Inert atmosphere; Green chemistry

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonium formate; magnesium sulfate; triethylamine; trifluoroacetic acid; scandium tris(trifluoromethanesulfonate); zinc; In methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1021/co400010y

Reference yield:

N-butyl-4-methoxycarbonyl-2-nitroaniline (234751-01-0) → methyl 1-n-butyl-2-[3-(cyclohexylamino)-2-(2-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-1H-benzo[d]imidazole-5-carboxylate (1430101-60-2)

Guidance literature:

Multi-step reaction with 4 steps

1: zinc; ammonium formate / methanol / 0.08 h / 90 °C / Microwave irradiation; Inert atmosphere

2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.17 h / 160 °C / Microwave irradiation; Inert atmosphere

3: trifluoroacetic acid; magnesium sulfate / 1,2-dichloro-ethane / 0.17 h / 130 °C / Microwave irradiation; Inert atmosphere

4: scandium tris(trifluoromethanesulfonate) / neat (no solvent) / 135 °C / Microwave irradiation; Inert atmosphere; Green chemistry

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonium formate; magnesium sulfate; triethylamine; trifluoroacetic acid; scandium tris(trifluoromethanesulfonate); zinc; In methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1021/co400010y

upstream raw materials:

4-fluoro-3-nitro-benzoic acid methyl ester

3-nitro-4-fluorobenzoic acid

N-butyl-4-methoxycarbonyl-2-nitroaniline

methyl 3-amino-4-(n-butylamino)benzoate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1430101-60-2 methyl 1-n-butyl-2-[3-(cyclohexylamino)-2-(2-fluorophenyl)imidazo[1,2-a]pyridin-8-yl]-1H-benzo[d]imidazole-5-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send