3-(4-chlorophenyl)-3-(3,4-dichlorophenyl)methoxyazetidine hydrochloride

Base Information

Chemical Name:3-(4-chlorophenyl)-3-(3,4-dichlorophenyl)methoxyazetidine hydrochloride
CAS No.:1447464-18-7
Molecular Formula:C₁₆H₁₄Cl₃NO*ClH
Molecular Weight:379.113
Hs Code.:

Synonyms:3-(4-chlorophenyl)-3-(3,4-dichlorophenyl)methoxyazetidine hydrochloride

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Chemical Property of 3-(4-chlorophenyl)-3-(3,4-dichlorophenyl)methoxyazetidine hydrochloride

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Technology Process of 3-(4-chlorophenyl)-3-(3,4-dichlorophenyl)methoxyazetidine hydrochloride

There total 3 articles about 3-(4-chlorophenyl)-3-(3,4-dichlorophenyl)methoxyazetidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1-boc-3-(4-chlorophenyl)-3-(3,4-dichlorophenyl)methoxyazetidine

: 1447464-18-7
3-(4-chlorophenyl)-3-(3,4-dichlorophenyl)methoxyazetidine hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃;
DOI:10.1016/j.bmcl.2013.05.071

Reference yield:

: 1447464-04-1
tert-butyl 3-(4-chlorophenyl)-3-hydroxyazetidine-1-carboxylate

: 1447464-18-7
3-(4-chlorophenyl)-3-(3,4-dichlorophenyl)methoxyazetidine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; sodium hydroxide / dichloromethane / Reflux

2: hydrogenchloride / ethyl acetate / 20 °C

With hydrogenchloride; tetrabutylammomium bromide; sodium hydroxide; In dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2013.05.071

Reference yield:

: 106-39-8
bromochlorobenzene

: 1447464-18-7
3-(4-chlorophenyl)-3-(3,4-dichlorophenyl)methoxyazetidine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran; hexane / 0.17 h / -78 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere

1.3: 20 °C / Inert atmosphere

2.1: tetrabutylammomium bromide; sodium hydroxide / dichloromethane / Reflux

3.1: hydrogenchloride / ethyl acetate / 20 °C

With hydrogenchloride; tetrabutylammomium bromide; sodium hydroxide; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2013.05.071