(S)-(E)-S-4-cyclohexyl-2-(3-methoxyphenyl)but-3-en-2-yl methylcarbamothioate

Base Information

Chemical Name:(S)-(E)-S-4-cyclohexyl-2-(3-methoxyphenyl)but-3-en-2-yl methylcarbamothioate
CAS No.:1613417-22-3
Molecular Formula:C₁₉H₂₇NO₂S
Molecular Weight:333.495
Hs Code.:

Synonyms:(S)-(E)-S-4-cyclohexyl-2-(3-methoxyphenyl)but-3-en-2-yl methylcarbamothioate

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Chemical Property of (S)-(E)-S-4-cyclohexyl-2-(3-methoxyphenyl)but-3-en-2-yl methylcarbamothioate

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Technology Process of (S)-(E)-S-4-cyclohexyl-2-(3-methoxyphenyl)but-3-en-2-yl methylcarbamothioate

There total 6 articles about (S)-(E)-S-4-cyclohexyl-2-(3-methoxyphenyl)but-3-en-2-yl methylcarbamothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1415351-95-9
(S)-(E)-S-4-cyclohexylbut-3-en-2-yl 3-methoxyphenyl(methyl)carbamothioate

: 1613417-22-3
(S)-(E)-S-4-cyclohexyl-2-(3-methoxyphenyl)but-3-en-2-yl methylcarbamothioate

Guidance literature:: (S)-(E)-S-4-cyclohexylbut-3-en-2-yl 3-methoxyphenyl(methyl)carbamothioate; With n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; at -78 - -60 ℃; Inert atmosphere;

With propionic acid; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1039/c4cc02596b

Reference yield:

: 79646-42-7,106499-63-2,120849-47-0,130930-52-8,18736-82-8,137764-95-5,79605-62-2
(E)-1-cyclohexyl-2-buten-1-ol

: 1613417-22-3
(S)-(E)-S-4-cyclohexyl-2-(3-methoxyphenyl)but-3-en-2-yl methylcarbamothioate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap / 1,2-dichloro-ethane / 26 h / 40 °C / Inert atmosphere

2.1: benzotriazol-1-ol / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere; Reflux

3.1: diisopropylamine; lithium chloride; n-butyllithium / tetrahydrofuran / -78 - -60 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

With dmap; n-butyllithium; benzotriazol-1-ol; diisopropylamine; lithium chloride; In tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1039/c4cc02596b

Reference yield:

: 18736-82-8
1-cyclohexyl-but-2-en-1-ol

: 1613417-22-3
(S)-(E)-S-4-cyclohexyl-2-(3-methoxyphenyl)but-3-en-2-yl methylcarbamothioate

Guidance literature:: Multi-step reaction with 5 steps

1.1: manganese(IV) oxide / chloroform / 132 h / 40 °C / Inert atmosphere

2.1: trans-RuCl₂((R)-2,2'-bis(di-3,5-xylylphosphino)-1,1'-binaphthyl)((R)-1,1-di(4-anisyl)-2-isopropyl-1,2-ethylenediamine); hydrogen; potassium carbonate / isopropyl alcohol / 168 h / 30 °C / 30003 Torr / Autoclave

3.1: dmap / 1,2-dichloro-ethane / 26 h / 40 °C / Inert atmosphere

4.1: benzotriazol-1-ol / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere; Reflux

5.1: diisopropylamine; lithium chloride; n-butyllithium / tetrahydrofuran / -78 - -60 °C / Inert atmosphere

5.2: -78 - 20 °C / Inert atmosphere

With dmap; manganese(IV) oxide; n-butyllithium; trans-RuCl₂((R)-2,2'-bis(di-3,5-xylylphosphino)-1,1'-binaphthyl)((R)-1,1-di(4-anisyl)-2-isopropyl-1,2-ethylenediamine); hydrogen; potassium carbonate; benzotriazol-1-ol; diisopropylamine; lithium chloride; In tetrahydrofuran; chloroform; 1,2-dichloro-ethane; isopropyl alcohol;
DOI:10.1039/c4cc02596b